Targeted Therapeutic Strategies for the Treatment of Cancer

被引：14
作者：
Victoir, Benjamin [1 ]
Croix, Cecile [1 ]
Gouilleux, Fabrice [2 ]
Prie, Gildas [1 ]
机构：
[1] Fac Med, Equipe Mecanismes Proteolyt Inflammat, INSERM UMR 1100 CEPR, 10 Blvd Tonnelle,BP 3223, F-37032 Tours 01, France
[2] Fac Med, Equipe Infect Resp & Immunite, INSERM UMR 1100 CEPR, 10 Blvd Tonnelle,BP 3223, F-37032 Tours 01, France
来源：
CANCERS | 2024年 / 16卷 / 02期
关键词：
targeted therapies; multitarget therapies; drug release; vectorization; drug combinations; nanocarriers; DUAL INHIBITORS; DRUG-DELIVERY; CONTROLLED-RELEASE; COLORECTAL-CANCER; CARBON NANOTUBES; MECHANISMS; RESISTANCE; NANOPARTICLES; COMBINATIONS; ACTIVATION;
D O I：
10.3390/cancers16020461
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Simple Summary Today, a significant issue in treating the most common cancers is their resistance to current treatment options like chemotherapy, radiotherapy, or immunotherapy. Drug combinations and/or dual inhibitors offer a promising alternative strategy to overcome this resistance. The purpose of this review is to present various existing options for the simultaneous administration of distinct drugs.Abstract Extensive research is underway to develop new therapeutic strategies to counteract therapy resistance in cancers. This review presents various strategies to achieve this objective. First, we discuss different vectorization platforms capable of releasing drugs in cancer cells. Second, we delve into multitarget therapies using drug combinations and dual anticancer agents. This section will describe examples of multitarget therapies that have been used to treat solid tumors.
引用
收藏
页数：18
相关论文
共 77 条
  • [1] High-throughput docking for lead generation
    Abagyan, R
    Totrov, M
    [J]. CURRENT OPINION IN CHEMICAL BIOLOGY, 2001, 5 (04) : 375 - 382
  • [2] Epidermal growth factor receptor-targeted photosensitizer selectively inhibits EGFR signaling and induces targeted phototoxicity in ovarian cancer cells
    Abu-Yousif, Adnan O.
    Moor, Anne C. E.
    Zheng, Xiang
    Savellano, Mark D.
    Yu, Weiping
    Selbo, Pal K.
    Hasan, Tayyaba
    [J]. CANCER LETTERS, 2012, 321 (02) : 120 - 127
  • [3] Controlled Drug Delivery Systems: Current Status and Future Directions
    Adepu, Shivakalyani
    Ramakrishna, Seeram
    [J]. MOLECULES, 2021, 26 (19):
  • [4] [Anonymous], About us
  • [5] Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases
    Apsel, Beth
    Blair, Jimmy A.
    Gonzalez, Beatriz
    Nazif, Tamim M.
    Feldman, Morri E.
    Aizenstein, Brian
    Hoffman, Randy
    Williams, Roger L.
    Shokat, Kevan M.
    Knight, Zachary A.
    [J]. NATURE CHEMICAL BIOLOGY, 2008, 4 (11) : 691 - 699
  • [6] Antibody-Antisense Oligonucleotide Conjugate Downregulates a Key Gene in Glioblastoma Stem Cells
    Arnold, Amy E.
    Malek-Adamian, Elise
    Le, Phuong U.
    Meng, Anika
    Martinez-Montero, Saul
    Petrecca, Kevin
    Damha, Masad J.
    Shoichet, Molly S.
    [J]. MOLECULAR THERAPY-NUCLEIC ACIDS, 2018, 11 : 518 - 527
  • [7] Advancements in the use of carbon nanotubes for antenna realization
    Arun, Henridass
    [J]. AEU-INTERNATIONAL JOURNAL OF ELECTRONICS AND COMMUNICATIONS, 2021, 136
  • [8] Antibody-Mediated Delivery of Anti-KRAS-siRNA In Vivo Overcomes Therapy Resistance in Colon Cancer
    Baeumer, Sebastian
    Baeumer, Nicole
    Appel, Neele
    Terheyden, Lisa
    Fremerey, Julia
    Schelhaas, Sonja
    Wardelmann, Eva
    Buchholz, Frank
    Berdel, Wolfgang E.
    Mueller-Tidow, Carsten
    [J]. CLINICAL CANCER RESEARCH, 2015, 21 (06) : 1383 - 1394
  • [9] Diagnosis and Treatment of Metastatic Colorectal Cancer: A Review
    Biller, Leah H.
    Schrag, Deborah
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2021, 325 (07): : 669 - 685
  • [10] [Anonymous], 2020, CA Cancer J Clin, V70, P313, DOI [10.3322/caac.21492, 10.3322/caac.21609]
12345678