Fever and antibiotic use in maternal urinary tract infections during pregnancy and risk of congenital heart defects: Findings from the National Birth Defects Prevention Study

被引：0

作者：

Patel, Jenil ^{[1
,2
,3
]}

Politis, Maria D. ^{[2
,3
,4
]}

Howley, Meredith M. ^{[5
]}

Browne, Marilyn L. ^{[5
,6
]}

Bolin, Elijah H. ^{[7
,8
]}

Ailes, Elizabeth C. ^{[9
]}

Johnson, Candice Y. ^{[10
]}

Magann, Everett ^{[11
]}

Nembhard, Wendy N. ^{[2
,3
]}

机构：

[1] Univ Texas Hlth Sci Ctr Houston UTHlth, Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Dallas, TX USA

[2] Univ Arkansas Med Sci, Fay W Boozman Coll Publ Hlth, Dept Epidemiol, 4301 West Markham St,Slot 820, Little Rock, AR 72205 USA

[3] Univ Arkansas Med Sci, Fay W Boozman Coll Publ Hlth, Arkansas Ctr Birth Defects Res & Prevent, Little Rock, AR 72205 USA

[4] Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York, NY 10029 USA

[5] New York State Dept Hlth, Birth Defects Registry, Albany, NY USA

[6] SUNY Albany, Dept Epidemiol & Biostat, Sch Publ Hlth, Rensselaer, NY USA

[7] Univ Arkansas Med Sci, Dept Pediat, Sect Pediat Cardiol, Little Rock, AR 72205 USA

[8] Arkansas Childrens Hosp, 800 Marshall St, Little Rock, AR 72202 USA

[9] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA

[10] Duke Univ, Dept Family Med & Community Hlth, Durham, NC USA

[11] Univ Arkansas Med Sci, Coll Med, Dept Obstet & Gynecol, Little Rock, AR 72205 USA

来源：

BIRTH DEFECTS RESEARCH | 2024年 / 116卷 / 01期

关键词：

CHDs; congenital heart defects; fever; maternal infections; pregnancy; UTI; ABNORMALITIES; HYPERTHERMIA; ASSOCIATION; WOMEN;

D O I：

10.1002/bdr2.2281

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

BackgroundPrevious studies report an association between prenatal maternal urinary tract infections (UTI) and specific congenital heart defects (CHDs); however, the role of fever and antibiotic use on this association is poorly understood. Using data from the National Birth Defects Prevention Study, we examined whether the relationship between maternal UTIs during the periconceptional period and occurrence of CHDs is modified by the presence of fever due to UTI and corresponding antibiotic use among 11,704 CHD case infants and 11,636 live-born control infants.MethodsInformation on UTIs, fever associated with UTI and antibiotic use (sulfonamides, nitrofurantoin, cephalosporins, penicillin, macrolides, and quinolones) during pregnancy were obtained using a computer-assisted telephone interview. Using unconditional multivariable logistic regression, we calculated adjusted odds ratios (ORs) to determine the association between maternal UTIs and subtypes of CHDs. Analyses were stratified by the presence of fever and medication use associated with UTI.ResultsThe prevalence of UTIs during the periconceptional period was 7.6% in control mothers, and 8.7% in case mothers. In the absence of fever, UTI was associated with secundum atrial septal defects (ASD) (OR 1.3; 95% confidence interval [CI] 1.1-1.5) and in the absence of antibiotics, UTI was associated with conotruncal defects as a group and for four specific CHDs. When fever and UTI occurred concomitantly, no significantly elevated odds ratios were noticed for any subtypes of CHD. Among women with UTIs who used antibiotics, an elevated but statistically non-significant estimate was observed for secundum ASD (OR 1.4; 95% CI 1.0-2.0).ConclusionFindings in the present study suggest that fever due to UTI and corresponding maternal antibiotic use do not substantially modify the association between maternal UTIs and specific CHDs in offspring. Further studies with larger sample sizes are warranted to guide clinical management of UTIs during the periconceptional period.

引用

页数：12

共 30 条

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