Extracellular vesicles: Emerging mediators of cell communication in gastrointestinal cancers exhibiting metabolic abnormalities

被引：5

作者：

Pourali, Ghazaleh ^{[1
]}

Zafari, Nima ^{[1
]}

Fiuji, Hamid ^{[2
]}

Batra, Jyotsna ^{[3
,11
,12
]}

Nazari, Elham ^{[4
]}

Khazaei, Majid ^{[1
]}

Hassanian, Seyed Mahdi ^{[1
]}

Vahabi, Mahrou ^{[2
]}

Kiani, MohammadAli ^{[1
]}

Ghayour-Mobarhan, Majid ^{[1
]}

Peters, Godefridus J. ^{[2
,5
]}

Ferns, Gordon A. ^{[6
]}

Lam, Alfred King-yin ^{[7
]}

Giovannetti, Elisa ^{[2
,9
]}

Avan, Amir ^{[1
,8
,10
]}

机构：

[1] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Iran

[2] VU Univ Med Ctr VUMC, Amsterdam UMC, Canc Ctr Amsterdam, Dept Med Oncol, Amsterdam, Netherlands

[3] Queensland Univ Technol, Fac Hlth, Sch Biomed Sci, Brisbane, Qld, Australia

[4] Shahid Beheshti Univ Med Sci, Sch Allied Med Sci, Dept Hlth Informat Technol & Management, Tehran, Iran

[5] Med Univ Gdansk, Biochem, Gdansk, Poland

[6] Brighton & Sussex Med Sch, Div Med Educ, Falmer BN1 9PH, Sussex, England

[7] Griffith Univ, Sch Med & Dent, Gold Coast Campus, Gold Coast, Qld 4222, Australia

[8] Univ Warith Al Anbiyaa, Coll Med, Karbala, Iraq

[9] Fdn Pisana Sci, AIRC Start Unit, Canc Pharmacol Lab, Pisa, Italy

[10] Queensland Univ Technol, Fac Hlth, Sch Biomed Sci, Brisbane, Australia

[11] Queensland Univ Technol, Translat Res Inst, Brisbane, Australia

[12] Queensland Univ Technol, Ctr Genom & Personalised Hlth, Brisbane, Australia

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2023年 / 73卷

基金：

英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

Extracellular vesicles; Tumour microenvironment; Gastrointestinal cancers; Hepatopancreatobiliary cancer; Metabolic reprogramming; Exosomal cargos; PANCREATIC-CANCER; COLORECTAL-CANCER; DENDRITIC CELLS; PROMOTE ANGIOGENESIS; PLASMA-MEMBRANE; EXOSOMES; FIBROBLASTS; MICROVESICLES; EXPRESSION; RELEASE;

D O I：

10.1016/j.cytogfr.2023.08.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There is a complex interaction between pro-tumoural and anti-tumoural networks in the tumour microenvironment (TME). Throughout tumourigenesis, communication between malignant cells and various cells of the TME contributes to metabolic reprogramming. Tumour Dysregulation of metabolic pathways offer an evolutional advantage in the TME and enhance the tumour progression, invasiveness, and metastasis. Therefore, understanding these interactions within the TME is crucial for the development of innovative cancer treatments. Extracellular vesicles (EVs) serve as carriers of various materials that include microRNAs, proteins, and lipids that play a vital role in the communication between tumour cells and non-tumour cells. EVs are actively involved in the metabolic reprogramming process. This review summarized recent findings regarding the involvement of EVs in the metabolic reprogramming of various cells in the TME of gastrointestinal cancers. Additionally, we highlight identified microRNAs involved in the reprogramming process in this group of cancers and explained the abnormal tumour metabolism targeted by exosomal cargos as well as the novel potential therapeutic approaches.

引用

页码：101 / 113

页数：13

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