Plasma and tissue kinetics of enrofloxacin and its metabolite, ciprofloxacin, in yellow catfish (Pelteobagrus fulvidraco) after a single oral administration at different temperatures

被引:5
作者
Xu, Ning [1 ,2 ,4 ]
Sun, Weiyu [1 ,3 ]
Zhang, Huan [1 ,3 ]
Liu, Yongtao [1 ,2 ]
Dong, Jing [1 ,2 ]
Zhou, Shun [1 ,2 ]
Yang, Yibin [1 ,2 ]
Yang, Qiuhong [1 ,2 ]
Ai, Xiaohui [1 ,2 ,4 ]
机构
[1] Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan 430223, Peoples R China
[2] Hu Bei Prov Engn & Technol Res Ctr Aquat Prod Qual, Wuhan 430223, Peoples R China
[3] Wuhan Polytech Univ, Coll Food Sci & Engn, Wuhan 430023, Peoples R China
[4] Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, 8 Wuda Pk Rd 1, Wuhan 430223, Hubei, Peoples R China
来源
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY | 2023年 / 266卷
基金
中国国家自然科学基金;
关键词
Pharmacokinetics; Enrofloxacin; Ciprofloxacin; Yellow catfish; Different temperatures; TILAPIA OREOCHROMIS-NILOTICUS; CARP CARASSIUS-AURATUS; CRUCIAN CARP; DEPENDENT PHARMACOKINETICS; DICENTRARCHUS-LABRAX; FLORFENICOL AMINE; SEA BASS; DISPOSITION; DOXYCYCLINE; INJECTION;
D O I
10.1016/j.cbpc.2023.109554
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The objective of this study was to examine the pharmacokinetic (PK) properties of enrofloxacin (EF) and its metabolite, ciprofloxacin (CF), in yellow catfish (Pelteobagrus fulvidraco) after a single oral dose of EF at 20 mg/ kg at 20, 25, and 30 degrees C. Samples were collected at pre-designed time points and determined by high-performance liquid chromatography with a fluorescent detector. Results showed that most concentrations of EF and CF in plasma and tissues at the same time point at different temperatures were statistically significant. With the increase in temperature, the terminal half-life (T-1/2 lambda z) of EF and CF was first reduced from 20 to 25 degrees C but elevated from 25 to 30 degrees C in plasma, muscle + skin, gill, liver, and kidney, respectively. The area under the plasma concentration-time curves (AUC(last)) of EF were all decreased in plasma, muscle + skin, and gill except for that of EF in the liver and kidney. However, the AUC(last) and the apparent metabolic rate of CF were exhibited first elevated and then decreased trend. The apparent volume of distribution (Vz_F) of EF was first reduced from 20 to 25 degrees C but increased at 30 degrees C. The apparent total body clearance (CL_F) of EF was increased from 0.15 to 0.32 L/ h center dot kg with the temperature elevation. These indicated that increased temperature markedly affected the PKs of EF and CF in yellow catfish. Through in-depth analysis, the EF dosage of 20 mg/kg is appropriate to use in yellow catfish at 20 and 25 degrees C but 30 degrees C.
引用
收藏
页数:10
相关论文
共 55 条
[1]  
Brill R., 1992, COLLECT REPR, V1, P237
[2]   Temperature-Dependent Residue Depletion Regularities of Tiamulin in Nile Tilapia (Oreochromis niloticus) Following Multiple Oral Administrations [J].
Cao, Cuiyv ;
Liu, Yongtao ;
Zhang, Guodong ;
Dong, Jing ;
Xu, Ning ;
Zhou, Shun ;
Yang, Yibin ;
Yang, Qiuhong ;
Ai, Xiaohui .
FRONTIERS IN VETERINARY SCIENCE, 2021, 8
[3]   Mechanisms of quinolone action and resistance: where do we stand? [J].
Correia, Susana ;
Poeta, Patricia ;
Hebraud, Michel ;
Capelo, Jose Luis ;
Igrejas, Gilberto .
JOURNAL OF MEDICAL MICROBIOLOGY, 2017, 66 (05) :551-559
[4]   The disposition of enrofloxacin in seabream (Sparus aurata L.) after single intravenous injection or from medicated feed administration [J].
della Rocca, G ;
Di Salvo, A ;
Malvisi, J ;
Sello, M .
AQUACULTURE, 2004, 232 (1-4) :53-62
[5]  
Dong Jing Dong Jing, 2017, Zhongguo Yufang Shouyi Xuebao / Chinese Journal of Preventive Veterinary Medicine, V39, P897
[6]  
Ellis A.E., 1978, P13
[7]   Comparative pharmacokinetics of enrofloxacin in healthy and Aeromonas hydrophila-infected crucian carp (Carassius auratus gibelio) [J].
Fan, J. ;
Shan, Q. ;
Wang, J. ;
Liu, S. ;
Li, L. ;
Zheng, G. .
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 2017, 40 (05) :580-582
[8]   Pharmacokinetics of enrofloxacin in snakehead fish, Channa argus [J].
Fang, X. ;
Zhou, J. ;
Liu, X. .
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 2016, 39 (02) :209-212
[9]   Pharmacokinetics of enrofloxacin in allogynogenetic silver crucian carp, Carassius auratus gibelio [J].
Fang, X. ;
Liu, X. ;
Liu, W. ;
Lu, C. .
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 2012, 35 (04) :397-401
[10]   Provisional epidemiological cutoff values for standard broth microdilution susceptibility testing of Flavobacterium columnare [J].
Gieseker, C. M. ;
Crosby, T. C. ;
Woods, L. C., III .
JOURNAL OF FISH DISEASES, 2017, 40 (05) :679-686