Five new spirosterol saponins from Allii Macrostemonis Bulbus

被引：6

作者：

Wang, Rong ^{[1
]}

Wang, Lulu ^{[2
]}

Zhang, Manli ^{[3
]}

Guo, Yadi ^{[1
]}

Zhang, Jing ^{[1
]}

Ma, Guoxu ^{[3
]}

机构：

[1] Jilin Agr Univ, Coll Chinese Med Mat, Changchun 130118, Peoples R China

[2] Changchun Univ Sci & Technol, Coll Med, Changchun 130600, Peoples R China

[3] Peking Union Med Coll & Chinese Acad Med Sci, Inst Med Plant Dev, Key Lab Bioact Subst & Resource Utilizat Chinese H, Beijing 100193, Peoples R China

来源：

CHINESE JOURNAL OF NATURAL MEDICINES | 2023年 / 21卷 / 03期

关键词：

Allii Macrostemonis Bulbus; Spirosterol saponin; Antioxidant; POLYSACCHARIDES; GLYCOSIDES;

D O I：

10.1016/S1875-5364(23)60423-6

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Five new spirostanol saponins (1-5) and seven known compounds (6-12) were isolated from the n-butanol fraction of 75% ethanol extract of Allii Macrostemonis Bulbus. The identification and structural elucidation of all the isolates were performed through extensive 1D and 2D NMR experiments, HR-ESI-MS data analysis and comparisons with literature values. Antioxidant evalu-ation showed that compounds 6-11 exhibited certain scavenging effects on ABTS radical, where compounds 6, 7 and 11 had IC50 val-ues of 0.208, 0.057 and 0.014 mg center dot mL-1, respectively.

引用

页码：226 / 232

页数：7

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