Seeing the Future: A Review of Ocular Therapy

被引：13

作者：

Whalen, Maiya ^{[1
]}

Akula, Monica ^{[2
]}

McNamee, Shannon M. ^{[2
]}

Deangelis, Margaret M. ^{[3
]}

Haider, Neena B. ^{[2
,4
]}

机构：

[1] Boston Coll, Dept Biol, Chestnut Hill, MA 02467 USA

[2] Shifa Precis, Boston, MA 02138 USA

[3] Univ Buffalo, Jacobs Sch Med & Biomed Sci, Dept Ophthalmol, Buffalo, NY 14203 USA

[4] Harvard Med Sch, Dept Cell Biol, Boston, MA 02138 USA

来源：

BIOENGINEERING-BASEL | 2024年 / 11卷 / 02期

关键词：

ocular therapy; gene therapy; cell therapy; retinal prosthesis; nanoparticles;

D O I：

10.3390/bioengineering11020179

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Ocular diseases present a unique challenge and opportunity for therapeutic development. The eye has distinct advantages as a therapy target given its accessibility, compartmentalization, immune privilege, and size. Various methodologies for therapeutic delivery in ocular diseases are under investigation that impact long-term efficacy, toxicity, invasiveness, and delivery range. While gene, cell, and antibody therapy and nanoparticle delivery directly treat regions that have been damaged by disease, they can be limited in the duration of the therapeutic delivery and have a focal effect. In contrast, contact lenses and ocular implants can more effectively achieve sustained and widespread delivery of therapies; however, they can increase dilution of therapeutics, which may result in reduced effectiveness. Current therapies either offer a sustained release or a broad therapeutic effect, and future directions should aim toward achieving both. This review discusses current ocular therapy delivery systems and their applications, mechanisms for delivering therapeutic products to ocular tissues, advantages and challenges associated with each delivery system, current approved therapies, and clinical trials. Future directions for the improvement in existing ocular therapies include combination therapies, such as combined cell and gene therapies, as well as AI-driven devices, such as cortical implants that directly transmit visual information to the cortex.

引用

页数：40

共 229 条

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