The Role of TGF-β3 in Radiation Response

被引：11
作者：
Hanson, Ingunn [1 ]
Pitman, Kathinka E. [1 ]
Edin, Nina F. J. [1 ]
机构：
[1] Univ Oslo, Dept Phys, N-0371 Oslo, Norway
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 08期
关键词：
cell cycle regulation; chemotherapy; fibrosis; ionizing radiation; radiomitigation; transforming growth factor beta; TGF-beta; 3; GROWTH-FACTOR-BETA; DOSE HYPER-RADIOSENSITIVITY; TGF-BETA; GENE-EXPRESSION; EXTRACELLULAR-MATRIX; STEM-CELLS; PULMONARY-FIBROSIS; ADAPTIVE RESPONSE; EPITHELIAL-CELLS; CLEFT-PALATE;
D O I：
10.3390/ijms24087614
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Transforming growth factor-beta 3 (TGF-beta 3) is a ubiquitously expressed multifunctional cytokine involved in a range of physiological and pathological conditions, including embryogenesis, cell cycle regulation, immunoregulation, and fibrogenesis. The cytotoxic effects of ionizing radiation are employed in cancer radiotherapy, but its actions also influence cellular signaling pathways, including that of TGF-beta 3. Furthermore, the cell cycle regulating and anti-fibrotic effects of TGF-beta 3 have identified it as a potential mitigator of radiation- and chemotherapy-induced toxicity in healthy tissue. This review discusses the radiobiology of TGF-beta 3, its induction in tissue by ionizing radiation, and its potential radioprotective and anti-fibrotic effects..
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页数：23
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