One pot synthesis of 1,3,4-oxadiazoles by Lewis acid catalyst and their study of 2D-QSAR, antimicrobial and anti-tubercular activities

In the present work, Lewis acid catalyzed reactions have been carried out between mefenamic acid, substituted aldehyde and semicarbazide in the presence of ZnCl2 to give the final compounds (E)-N-(2-(5-((substitutedene)amino)-1,3,4-oxadiazol-2-yl)phenyl)-2,3-dimethylaniline, A. The synthesized compounds have been characterized by IR, 1H NMR, 13C NMR, mass spectral studies and biologically screened for the antimicrobial, antitubercular and antimalarial activities. Among the screened molecules, the molecules A1, A3, A4, A6, A8, A9, A10 show activity against different antibacterial species. The compounds, active against different antifugal species are A3, A7, A8, A9 against C. albicans, compound A3 is active against A. niger. Whereas, compound A9 shows good antimycobacterial activity. Compound A6 having 4-hydroxybenzenesubstituent exhibits promising activity against P. falciparum antimalerial parasite.