Adipose Tissue-Derived Extracellular Vesicles: A Promising Biomarker and Therapeutic Strategy for Metabolic Disorders

被引：9

作者：

Liu, Wenhui ^{[1
,2
]}

Liu, Tianyan ^{[3
]}

Zhao, Qingyu ^{[4
]}

Ma, Junqiu ^{[1
,3
]}

Jiang, Jiajia ^{[1
,3
]}

Shi, Hui ^{[1
,2
]}

机构：

[1] Jiangsu Univ, Aoyang Inst Canc, Affiliated Aoyang Hosp, 279 Jingang Rd, Suzhou 215600, Jiangsu, Peoples R China

[2] Jiangsu Univ, Zhenjiang Key Lab High Technol Res sEVs Fdn & Tran, Sch Med, 301 Xuefu Rd, Zhenjiang 212013, Jiangsu, Peoples R China

[3] Jiangsu Univ, Ctr Lab Med, Affiliated Aoyang Hosp, 279 Jingang Rd,Zhangjiagang, Suzhou 215600, Jiangsu, Peoples R China

[4] Jiangsu Univ, Dept Nephrol, Affiliated Aoyang Hosp, 279 Jingang Rd,Zhangjiagang, Suzhou 215600, Jiangsu, Peoples R China

来源：

STEM CELLS INTERNATIONAL | 2023年 / 2023卷

基金：

中国国家自然科学基金;

关键词：

HYPOXIA-INDUCIBLE FACTORS; INHIBITS ADIPOGENESIS; INSULIN-RESISTANCE; ENDOTHELIAL-CELLS; BROWN FAT; IN-VITRO; OBESITY; EXOSOMES; INFLAMMATION; LIVER;

D O I：

10.1155/2023/9517826

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Adipose tissue plays an important role in systemic energy metabolism, and its dysfunction can lead to severe metabolic disorders. Various cells in adipose tissue communicate with each other to maintain metabolic homeostasis. Extracellular vesicles (EVs) are recognized as novel medium for remote intercellular communication by transferring various bioactive molecules from parental cells to distant target cells. Increasing evidence suggests that the endocrine functions of adipose tissue and even the metabolic homeostasis are largely affected by different cell-derived EVs, such as insulin signaling, lipolysis, and metabolically triggered inflammation regulations. Here, we provide an overview focused on the role of EVs released by different cell types of adipose tissue in metabolic diseases and their possible molecular mechanisms and highlight the potential applications of EVs as biomarkers and therapeutic targets. Moreover, the current EVs-based therapeutic strategies have also been discussed. This trial is registered with NCT05475418.

引用

页数：16

共 178 条

[1] Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling [J].

Adachi, Yusuke ;

Ueda, Kazutaka ;

Nomura, Seitaro ;

Ito, Kaoru ;

Katoh, Manami ;

Katagiri, Mikako ;

Yamada, Shintaro ;

Hashimoto, Masaki ;

Zhai, Bowen ;

Numata, Genri ;

Otani, Akira ;

Hinata, Munetoshi ;

Hiraike, Yuta ;

Waki, Hironori ;

Takeda, Norifumi ;

Morita, Hiroyuki ;

Ushiku, Tetsuo ;

Yamauchi, Toshimasa ;

Takimoto, Eiki ;

Komuro, Issei .

NATURE COMMUNICATIONS, 2022, 13 (01)

[2] Fat-Secreted Ceramides Regulate Vascular Redox State and Influence Outcomes in Patients With Cardiovascular Disease [J].

Akawi, Nadia ;

Checa, Antonio ;

Antonopoulos, Alexios S. ;

Akoumianakis, Ioannis ;

Daskalaki, Evangelia ;

Kotanidis, Christos P. ;

Kondo, Hidekazu ;

Lee, Kirsten ;

Yesilyurt, Dilan ;

Badi, Ileana ;

Polkinghorne, Murray ;

Akbar, Naveed ;

Lundgren, Julie ;

Chuaiphichai, Surawee ;

Choudhury, Robin ;

Neubauer, Stefan ;

Channon, Keith M. ;

Torekov, Signe S. ;

Wheelock, Craig E. ;

Antoniades, Charalambos .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2021, 77 (20) :2494-2513

[3] Adipose Tissue-Derived Stem Cells: Immunomodulatory Effects and Therapeutic Potential [J].

Al-Ghadban, Sara ;

Bunnell, Bruce A. .

PHYSIOLOGY, 2020, 35 (02) :125-133

[4] Exosomes from adipose-derived stem cells and application to skin wound healing [J].

An, Yang ;

Lin, Shuyan ;

Tan, Xiaojie ;

Zhu, Shiou ;

Nie, Fangfei ;

Zhen, Yonghuan ;

Gu, Luosha ;

Zhang, Chunlei ;

Wang, Baicheng ;

Wei, Wei ;

Li, Dong ;

Wu, Junhao .

CELL PROLIFERATION, 2021, 54 (03)

[5] Defining the lineage of thermogenic perivascular adipose tissue [J].

Angueira, Anthony R. ;

Sakers, Alexander P. ;

Holman, Corey D. ;

Cheng, Lan ;

Arbocco, Michelangella N. ;

Shamsi, Farnaz ;

Lynes, Matthew D. ;

Shrestha, Rojesh ;

Okada, Chihiro ;

Batmanov, Kirill ;

Susztak, Katalin ;

Tseng, Yu-Hua ;

Liaw, Lucy ;

Seale, Patrick .

NATURE METABOLISM, 2021, 3 (04) :469-+

[6] Epicardial adipose tissue and cardiovascular diseases [J].

Ansaldo, Anna Maria ;

Montecucco, Fabrizio ;

Sahebkar, Amirhossein ;

Dallegri, Franco ;

Carbone, Federico .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2019, 278 :254-260

[7] Human Wharton's jelly mesenchymal stem cells promote skin wound healing through paracrine signaling [J].

Arno, Anna I. ;

Amini-Nik, Saeid ;

Blit, Patrick H. ;

Al-Shehab, Mohammed ;

Belo, Cassandra ;

Herer, Elaine ;

Tien, Col Homer ;

Jeschke, Marc G. .

STEM CELL RESEARCH & THERAPY, 2014, 5

[8] Adipose tissue browning and metabolic health [J].

Bartelt, Alexander ;

Heeren, Joerg .

NATURE REVIEWS ENDOCRINOLOGY, 2014, 10 (01) :24-36

[9] Sensory and sympathetic nervous system control of white adipose tissue lipolysis [J].

Bartness, Timothy J. ;

Shrestha, Y. B. ;

Vaughan, C. H. ;

Schwartz, G. J. ;

Song, C. K. .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2010, 318 (1-2) :34-43

[10] Reduced early insulin secretion in the etiology of type 2 diabetes mellitus in Pima Indians [J].

Bogardus, C ;

Tataranni, PA .

DIABETES, 2002, 51 :S262-S264

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