PANoptosis: Mechanism and Role in Pulmonary Diseases

被引：26
作者：
Chen, Shiyi [1 ]
Jiang, Jiacheng [1 ]
Li, Tongfu [1 ]
Huang, Longshuang [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Shanghai Frontiers Sci Ctr Drug Target Identificat, Sch Pharm, Shanghai 200240, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 20期
关键词：
PANoptosis; pulmonary disease; pyroptosis; apoptosis; necroptosis; PROGRAMMED CELL-DEATH; INNATE IMMUNE; GASDERMIN D; INFLAMMASOME ACTIVATION; NEUTROPHIL ELASTASE; NLRP3; INFLAMMASOME; BACTERIAL LIGANDS; AIM2; UP-REGULATION; CYTOCHROME-C;
D O I：
10.3390/ijms242015343
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
PANoptosis is a newly defined programmed cell death (PCD) triggered by a series of stimuli, and it engages three well-learned PCD forms (pyroptosis, apoptosis, necroptosis) concomitantly. Normally, cell death is recognized as a strategy to eliminate unnecessary cells, inhibit the proliferation of invaded pathogens and maintain homeostasis; however, vigorous cell death can cause excessive inflammation and tissue damage. Acute lung injury (ALI) and chronic obstructive pulmonary syndrome (COPD) exacerbation is related to several pathogens (e.g., influenza A virus, SARS-CoV-2) known to cause PANoptosis. An understanding of the mechanism and specific regulators may help to address the pathological systems of these diseases. This review presents our understanding of the potential mechanism of PANoptosis and the role of PANoptosis in different pulmonary diseases.
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页数：18
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