Emerging Relationship between the Gut Microbiome and Prostate Cancer

被引：19

作者：

Matsushita, Makoto ^{[1
]}

Fujita, Kazutoshi ^{[1
,2
,5
]}

Hatano, Koji ^{[1
]}

De Velasco, Marco A. ^{[2
,3
]}

Tsujimura, Akira ^{[4
]}

Uemura, Hirotsugu ^{[2
]}

Nonomura, Norio ^{[1
]}

机构：

[1] Osaka Univ, Dept Urol, Grad Sch Med, Suita, Japan

[2] Kindai Univ, Dept Urol, Fac Med, Higashiosaka, Japan

[3] Kindai Univ, Dept Genome Biol, Fac Med, Osakasayama, Japan

[4] Juntendo Univ Urayasu Hosp, Dept Urol, Urayasu, Japan

[5] Kindai Univ, Dept Urol, Fac Med, 377-2 Oono higashi, Osakasayama, Osaka 5898511, Japan

来源：

WORLD JOURNAL OF MENS HEALTH | 2023年 / 41卷 / 04期

基金：

日本学术振兴会;

关键词：

Bacteria; Gut microbiome; Host microbial interactions; Prostate cancer; Testosterone; INTESTINAL MICROBIOTA; INFLAMMATION; PROGRESSION; RISK; PATHOGENESIS; ACTIVATION; EXPOSURE; FOLATE; CELLS;

D O I：

10.5534/wjmh.220202

中图分类号：

R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

摘要：

The human gut microbiota changes under the influence of environmental and genetic factors, affecting human health. Exten-sive studies have revealed that the gut microbiome is closely associated with many non-intestinal diseases. Among these, the influence of the gut microbiome on cancer biology and the efficacy of cancer therapy has attracted much attention. Prostate cancer cells are affected by direct contact with the microbiota of local tissues and urine, and a relationship between prostate cancer cells and the gut microbiota has been suggested. In the human gut microbiota, bacterial composition differs depend-ing on prostate cancer characteristics, such as histological grade and castration resistance. Moreover, the involvement of several intestinal bacteria in testosterone metabolism has been demonstrated, suggesting that they may affect prostate cancer progression and treatment through this mechanism. Basic research indicates that the gut microbiome also plays an important role in the underlying biology of prostate cancer through multiple mechanisms owing to the activity of microbial-derived me-tabolites and components. In this review, we describe the evidence surrounding the emerging relationship between the gut microbiome and prostate cancer, termed the "gut-prostate axis."

引用

页码：759 / 768

页数：10

共 87 条

[1] The Gut Microbiota and Inflammation: An Overview [J].