Lysophospholipids and branched chain amino acids are associated with aging: a metabolomics-based study of Chinese adults

被引：7

作者：

Pan, Yiming ^{[1
]}

Liu, Pan ^{[1
]}

Li, Shijie ^{[1
]}

Li, Bowen ^{[2
]}

Li, Yun ^{[1
]}

Ma, Lina ^{[1
]}

机构：

[1] Capital Med Univ, Xuanwu Hosp, Natl Res Ctr Geriatr Med, Dept Geriatr, Beijing 100053, Peoples R China

[2] LipidALL Technol Co Ltd, Changzhou 213022, Jiangsu, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICAL RESEARCH | 2023年 / 28卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Aging; Metabolomics; Lysophospholipid; Branched-chain amino acid; Biomarker; AGE; HEALTH; TOOL;

D O I：

10.1186/s40001-023-01021-w

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

BackgroundAging is an inevitable process associated with impairments in multiple organ systems, which increases the risk of comorbidity and disability, and reduces the health-span. Metabolomics is a powerful tool in aging research, which can reflect the characteristics of aging at the level of terminal metabolism, and may contribute to the exploration of aging mechanisms and the formulation of anti-aging strategies.MethodsTo identify possible biomarkers and pathways associated with aging using untargeted metabolomics methods, we performed liquid chromatography-mass spectrometry (LC-MS)-based untargeted metabolomics profiling on serum samples from 32 older adults and 32 sex-matched young controls.ResultsMetabolite profiling could distinguish the two groups. Among the 349 metabolites identified, 80-including lysophospholipids whose levels gradually decline-are possible candidate aging biomarkers. Valine, leucine and isoleucine degradation and biosynthesis were important pathways in aging, with reduced levels of l-isoleucine (r = - 0.30, p = 0.017) and l-leucine (r = - 0.32, p = 0.010) observed in older adults.ConclusionsWe preliminarily revealed the metabolite changes associated with aging in Chinese adults. Decreases in mitochondrial membrane-related lysophospholipids and dysfunction of branched-chain amino acid metabolism were determined to be the characteristics and promising research targets for aging.

引用

页数：9

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