Probenecid Inhibits Influenza A(H5N1) and A(H7N9) Viruses In Vitro and in Mice

被引：7

作者：

Murray, Jackelyn ^{[1
]}

Martin, David E. ^{[2
]}

Hosking, Sarah ^{[1
]}

Orr-Burks, Nichole ^{[1
]}

Hogan, Robert J. ^{[1
]}

Tripp, Ralph A. ^{[1
,2
]}

机构：

[1] Univ Georgia, Coll Vet Med Athens, Anim Hlth Res Ctr, Dept Infect Dis, Athens, GA 30605 USA

[2] TrippBio Inc, Jacksonville, FL 32256 USA

来源：

VIRUSES-BASEL | 2024年 / 16卷 / 01期

关键词：

highly pathogenic; HPAI; antiviral; avian influenza; PATHOGENIC AVIAN INFLUENZA; ANION TRANSPORTER 1; A H7N9 VIRUS; RECEPTOR-BINDING; HUMAN INFECTIONS; H5N1; ALPHA; GENE; EPIDEMIOLOGY; OSELTAMIVIR;

D O I：

10.3390/v16010152

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Avian influenza (AI) viruses cause infection in birds and humans. Several H5N1 and H7N9 variants are highly pathogenic avian influenza (HPAI) viruses. H5N1 is a highly infectious bird virus infecting primarily poultry, but unlike other AIs, H5N1 also infects mammals and transmits to humans with a case fatality rate above 40%. Similarly, H7N9 can infect humans, with a case fatality rate of over 40%. Since 1996, there have been several HPAI outbreaks affecting humans, emphasizing the need for safe and effective antivirals. We show that probenecid potently inhibits H5N1 and H7N9 replication in prophylactically or therapeutically treated A549 cells and normal human broncho-epithelial (NHBE) cells, and H5N1 replication in VeroE6 cells and mice.

引用

页数：15

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