Nanoscale β-TCP-Laden GelMA/PCL Composite Membrane for Guided Bone Regeneration

被引：47

作者：

Mahmoud, Abdel H. ^{[1
]}

Han, Yuanyuan ^{[1
,2
]}

Dal-Fabbro, Renan ^{[1
]}

Daghrery, Arwa ^{[1
,3
]}

Xu, Jinping ^{[1
]}

Kaigler, Darnell ^{[4
,5
]}

Bhaduri, Sarit B. ^{[6
,7
]}

Malda, Jos ^{[8
,9
,10
]}

Bottino, Marco C. ^{[1
,5
]}

机构：

[1] Univ Michigan, Sch Dent, Dept Cariol Restorat Sci & Endodont, Ann Arbor, MI 48109 USA

[2] Univ Hong Kong, Fac Dent, Appl Oral Sci & Community Dent Care, Hong Kong 999077, Peoples R China

[3] Jazan Univ, Sch Dent, Dept Restorat Dent Sci, Jazan 45142, Saudi Arabia

[4] Univ Michigan, Sch Dent, Dept Periodont & Oral Med, Coll Engn, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Coll Engn, Dept Biomed Engn, Ann Arbor, MI 48109 USA

[6] Univ Toledo, Dept Mech Ind & Mfg Engn, Toledo, OH 43606 USA

[7] Natl Sci Fdn, EEC Div, Directorate Engn, Alexandria, VA 22314 USA

[8] Regenerat Med Ctr Utrecht, NL-3584 CT Utrecht, Netherlands

[9] Univ Utrecht, Fac Vet Med, Dept Clin Sci, NL-3508 TC Utrecht, Netherlands

[10] Univ Med Ctr Utrecht, Dept Orthoped, NL-3584 CX Utrecht, Netherlands

来源：

ACS APPLIED MATERIALS & INTERFACES | 2023年 / 15卷 / 27期

基金：

美国国家卫生研究院;

关键词：

bone; regeneration; tissue engineering; electrospinning; extracellular matrix; gelatin; OPEN-FLAP DEBRIDEMENT; TISSUE REGENERATION; INTRABONY DEFECTS; BETA-TCP; FIBERS; SYSTEM;

D O I：

10.1021/acsami.3c03059

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Major advances in the field of periodontal tissue engineeringhavefavored the fabrication of biodegradable membranes with tunable physicaland biological properties for guided bone regeneration (GBR). Herein,we engineered innovative nanoscale beta-tricalcium phosphate (& beta;-TCP)-ladengelatin methacryloyl/polycaprolactone (GelMA/PCL-TCP) photocrosslinkablecomposite fibrous membranes via electrospinning. Chemo-morphologicalfindings showed that the composite microfibers had a uniform porousnetwork and & beta;-TCP particles successfully integrated within thefibers. Compared with pure PCL and GelMA/PCL, GelMA/PCL-TCP membranesled to increased cell attachment, proliferation, mineralization, andosteogenic gene expression in alveolar bone-derived mesenchymal stemcells (aBMSCs). Moreover, our GelMA/PCL-TCP membrane was able to promoterobust bone regeneration in rat calvarial critical-size defects, showingremarkable osteogenesis compared to PCL and GelMA/PCL groups. Altogether,the GelMA/PCL-TCP composite fibrous membrane promoted osteogenic differentiationof aBMSCs in vitro and pronounced bone formation in vivo. Our dataconfirmed that the electrospun GelMA/PCL-TCP composite has a strongpotential as a promising membrane for guided bone regeneration.

引用

页码：32121 / 32135

页数：15

共 53 条

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