Optimal blue light irradiation conditions for the treatment of acne vulgaris in a mouse model

被引:6
作者
Nakayama, Eiko [1 ]
Kushibiki, Toshihiro [2 ]
Mayumi, Yoshine [2 ]
Fushuku, Seigo [3 ]
Nakamura, Takahiro [4 ]
Kiyosawa, Tomoharu [1 ]
Ishihara, Miya [2 ]
Azuma, Ryuichi [1 ]
机构
[1] Natl Def Med Coll, Dept Plast Surg, 3-2 Namiki, Tokorozawa 3590042, Japan
[2] Natl Def Med Coll, Dept Med Engn, 3-2 Namiki, Tokorozawa 3590042, Japan
[3] Natl Def Med Coll, Ctr Lab Anim Sci, 3-2 Namiki, Tokorozawa 3590042, Japan
[4] Natl Def Med Coll, Lab Math, 3-2 Namiki, Tokorozawa 3590042, Japan
关键词
Acne vulgaris; Dermatologic conditions; Blue light irradiation; Light therapy; Light -emitting diode (LED); PROPIONIBACTERIUM-ACNES; PHOTOTHERAPY; LASER; UVA;
D O I
10.1016/j.jphotobiol.2023.112651
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Background: Although blue light is one of the therapeutic approaches used to treat acne vulgaris (AV), there is no consensus on its effectiveness. As a result, it is not recommended in the major acne vulgaris treatment guidelines.Objective: The goal of this study was to look into the mechanism, safety, and efficacy of blue light therapy. We achieved this by examining the pathological response, inflammation, and depth of light penetration in a mouse model of cystic AV. Methods: The aims of the study were addressed by exposing the mice to light with a wavelength of 415 nm under four different irradiation conditions. The exposure was done for five consecutive days followed by a no irradiation period of 72 h.Results: Blue light treatment was most effective when irradiation was performed at 100 mW/cm2 for 20 min for five consecutive days. Inflammatory responses emerged 72 h after the final irradiation dose was administered. These responses were not associated with apoptosis as cleaved caspase-3 staining revealed no significant increases in apoptosis in the skin under any of the tested conditions. Blue light reached the superficial layer of the acne cyst at 5% of the total irradiation power and was attenuated by half for every 50 mu m of progress through the cyst.Conclusion: In conclusion, blue light could control severe dermatologic inflammatory responses; therefore, it can be used to irradiate AV with high inflammation levels on a daily basis until improvement is observed. In addition, porphyrin, a metabolite of Cutibacterium acnes, and reactive oxygen species generated by the surrounding skin tissue may have essential roles in AV treatment.
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页数:9
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