Mitracarpus hirtus (L.) DC.: is a potential source for the exploitation of anticancer agents

被引：1
作者：
Malami, Ibrahim [1 ,2 ]
Batako, Muhammad Muhammad [1 ]
Alhasan, Alhasan Muhammad [3 ]
Abubakar, Ibrahim Babangida [4 ]
机构：
[1] Usmanu Danfodiyo Univ, Fac Pharmaceut Sci, Dept Pharmacognosy & Ethnopharm, Sokoto, Nigeria
[2] Usmanu Danfodiyo Univ, Ctr Adv Med Res & Training, Sokoto, Nigeria
[3] Usmanu Danfodiyo Univ, Fac Pharmaceut Sci, Dept Pharmaceut & Med Chem, Sokoto, Nigeria
[4] Kebbi State Univ Sci & Technol, Fac Life Sci, Dept Biochem, Aliero, Kebbi, Nigeria
来源：
NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 17期
关键词：
Mitracarpus hirtus; cancer; anticancer agents; MCF-7; apoptosis; APOPTOSIS;
D O I：
10.1080/14786419.2022.2140340
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Mitracarpus hirtus (L.) DC. is a weed plant commonly used for the treatment of eczema. The potential of the plant to treat cancer has not been emphasized, hence the need to explore its anticancer potential. M. hirtus was extracted and subjected to petition with solvents of increasing polarity. Its cytotoxic potential was evaluated against MCF-7, HepG2, and HeLa cells using the Neutral red assay and further verified through morphological assessment and DNA fragmentation assay. Crude chloroform fraction (CCF) displayed a cytotoxic effect on all the cell lines with low IC50 concentrations ranging from 11-17.87 mu g/mL. Morphological assessment of MCF-7 exposed to CCF indicates apoptotic cell death and is further confirmed by its DNA fragmentation. Our data suggest that M. hirtus is a potential source for mining anticancer agents.
引用
收藏
页码：2965 / 2968
页数：4
相关论文
共 12 条
  • [1] Influence of in vitro supplementation with lipids from conventional and Alpine milk on fatty acid distribution and cell growth of HT-29 cells
    Degen, Christian
    Lochner, Alfred
    Keller, Sylvia
    Kuhnt, Katrin
    Daenicke, Sven
    Jahreis, Gerhard
    [J]. LIPIDS IN HEALTH AND DISEASE, 2011, 10
  • [2] Ekalu Abiche, 2021, Scientific African, V11, DOI 10.1016/j.sciaf.2020.e00692
  • [3] The molecular mechanism of the anticancer effect of Artonin E in MDA-MB 231 triple negative breast cancer cells
    Etti, Imaobong Christopher
    Abdullah, Rasedee
    Kadir, Arifah
    Hashim, Najihah Mohd
    Yeap, Swee Keong
    Imam, Mustapha Umar
    Ramli, Faiqah
    Malami, Ibrahim
    Lam, Kian Lim
    Etti, Ubong
    Waziri, Peter
    Rahman, Marsitoh
    [J]. PLOS ONE, 2017, 12 (08):
  • [4] A rtonin E induces p53-independent G1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cells
    Etti, Imaobong Christopher
    Rasedee, Abdullah
    Hashim, Najihah Mohd
    Abdul, Ahmad Bustamam
    Kadir, Arifah
    Yeap, Swee Keong
    Waziri, Peter
    Malami, Ibrahim
    Lim, Kian Lam
    Etti, Christopher J.
    [J]. DRUG DESIGN DEVELOPMENT AND THERAPY, 2017, 11 : 865 - 879
  • [5] Anti-tumor Effect of Oleic Acid in Hepatocellular Carcinoma Cell Lines via Autophagy Reduction
    Giulitti, Federico
    Petrungaro, Simonetta
    Mandatori, Sara
    Tomaipitinca, Luana
    de Franchis, Valerio
    D'Amore, Antonella
    Filippini, Antonio
    Gaudio, Eugenio
    Ziparo, Elio
    Giampietri, Claudia
    [J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9
  • [6] In vitro anti-proliferative activities of the sterols and fatty acids isolated from the Persian Gulf sponge; Axinella sinoxea
    Jamebozorgi, Fatemeh Heidary
    Yousefzadi, Morteza
    Firuzi, Omidreza
    Nazemi, Meliika
    Jassbi, Amir Reza
    [J]. DARU-JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 27 (01) : 121 - 135
  • [7] Integration of medicinal plants into the traditional system of medicine for the treatment of cancer in Sokoto State, Nigeria
    Malami, Ibrahim
    Jagaba, Nasiru Muhammad
    Abubakar, Ibrahim Babangida
    Muhammad, Aliyu
    Alhassan, Alhassan Muhammad
    Waziri, Peter Maitama
    Yahaya, Ibrahim Zakiyya Yakubu
    Mshelia, Halilu Emmanuel
    Mathias, Sylvester Nefy
    [J]. HELIYON, 2020, 6 (09)
  • [8] Crude Extracts, Flavokawain B and Alpinetin Compounds from the Rhizome of Alpinia mutica Induce Cell Death via UCK2 Enzyme Inhibition and in Turn Reduce 18S rRNA Biosynthesis in HT-29 Cells
    Malami, Ibrahim
    Abdul, Ahmad Bustamam
    Abdullah, Rasedee
    Kassim, Nur Kartinee Bt
    Rosli, Rozita
    Yeap, Swee Keong
    Waziri, Peter
    Etti, Imaobong Christopher
    Bello, Muhammad Bashir
    [J]. PLOS ONE, 2017, 12 (01):
  • [9] Trans-vaccenic acid inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cells via a mitochondrial-mediated apoptosis pathway
    Song, Jian
    Wang, Yujie
    Fan, Xiaoqin
    Wu, Hanwei
    Han, Jinghong
    Yang, Ming
    Lu, Lu
    Nie, Guohui
    [J]. LIPIDS IN HEALTH AND DISEASE, 2019, 18 (1)
  • [10] Clausenidin from Clausena excavata induces apoptosis in hepG2 cells via the mitochondrial pathway
    Waziri, Peter M.
    Abdullah, Rasedee
    Yeap, Swee Keong
    Omar, Abdul Rahman
    Abdul, Ahmad Bustamam
    Kassim, Nur Kartinee
    Malami, Ibrahim
    Karunakaran, Thiruventhan
    Imam, Mustapha Umar
    [J]. JOURNAL OF ETHNOPHARMACOLOGY, 2016, 194 : 549 - 558
12