Immunomodulatory Effects of Microbiota-Derived Short-Chain Fatty Acids in Autoimmune Liver Diseases

被引：12

作者：

Zhang, Weici ^{[1
]}

Mackay, Charles R. ^{[2
]}

Gershwin, M. Eric ^{[1
]}

机构：

[1] Univ Calif Davis, Sch Med, Div Rheumatol Allergy & Clin Immunol, Davis, CA 95616 USA

[2] Monash Univ, Biomed Discovery Inst, Dept Microbiol, Infect & Immun Program, Melbourne, Vic, Australia

来源：

JOURNAL OF IMMUNOLOGY | 2023年 / 210卷 / 11期

基金：

美国国家卫生研究院;

关键词：

REGULATORY T-CELLS; HUMAN B-CELLS; G-PROTEIN; GUT MICROBIOTA; DIETARY FIBER; GRANZYME-B; RECEPTOR; METABOLITES; INDUCE; EXPRESSION;

D O I：

10.4049/jimmunol.2300016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nonpathogenic commensal microbiota and their metabolites and components are essential to maintain a tolerogenic environment and promote beneficial health effects. The metabolic environment critically impacts the outcome of immune responses and likely impacts autoimmune and allergic responses. Short-chain fatty acids (SCFAs) are the main metabolites produced by microbial fermentation in the gut. Given the high concentration of SCFAs in the gut and portal vein and their broad immune regulatory functions, SCFAs significantly influence immune tolerance and gut-liver immunity. Alterations of SCFA-producing bacteria and SCFAs have been identified in a multitude of inflammatory diseases. These data have particular significance in primary biliary cholangitis, primary sclerosing cholangitis, and autoimmune hepatitis because of the close proximity of the liver to the gut. In this focused review, we provide an update on the immunologic consequences of SCFA-producing microbiota and in particular on three dominant SCFAs in autoimmune liver diseases.

引用

页码：1629 / 1639

页数：11

共 139 条

[1] Comparative In silico Analysis of But Production Pathways in Gut Commensals and Pathogens [J].

Anand, Swadha ;

Kaur, Harrisham ;

Mande, Sharmila S. .

FRONTIERS IN MICROBIOLOGY, 2016, 7

[2] Short-chain fatty acid acetate triggers antiviral response mediated by RIG-I in cells from infants with respiratory syncytial virus bronchiolitis [J].

Antunes, Krist H. ;

Stein, Renato T. ;

Franceschina, Caroline ;

da Silva, Emanuelle F. ;

de Freitas, Deise N. ;

Silveira, Josiane ;

Mocellin, Magali ;

Leitao, Lidiane ;

Fachi, Jose L. ;

Pral, Lais P. ;

Gonzalez, Amanda ;

Oliveira, Sarah ;

Duarte, Leonardo ;

Cassao, Gisele ;

Goncalves, Joao I. B. ;

Reis, Tatiane M. ;

Abbadi, Bruno L. ;

Dornelles, Maiele ;

Sperotto, Nathalia D. M. ;

Rigo, Mauricio ;

Rodrigues, Hosana ;

Jones, Marcus ;

Epifanio, Matias ;

Guima, Suzana ;

Setubal, Joao C. ;

Jorge, Taissa R. ;

Mansur, Daniel S. ;

Mayer, Fabiana Q. ;

Varela, Ana Paula M. ;

Bizarro, Cristiano, V ;

Machado, Pablo ;

Basso, Luiz A. ;

Polack, Fernando P. ;

Custovic, Adnan ;

Vinolo, Marco A. R. ;

de Souza, Ana Paula D. .

EBIOMEDICINE, 2022, 77

[3] Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response [J].

Antunes, Krist Helen ;

Fachi, Jose Luis ;

de Paula, Rosemeire ;

da Silva, Emanuelle Fraga ;

Pral, Lais Passariello ;

dos Santos, Adara Aurea ;

Malaquias Dias, Greicy Brisa ;

Vargas, Jose Eduardo ;

Puga, Renato ;

Mayer, Fabiana Quoos ;

Maito, Fabio ;

Zarate-Blades, Carlos R. ;

Ajami, Nadim J. ;

St Ana, Marcella Ramos ;

Candreva, Thamiris ;

Rodrigues, Hosana Gomes ;

Schmiele, Marcio ;

Pedrosa Silva Clerici, Maria Teresa ;

Proenca-Modena, Jose Luiz ;

Vieira, Angelica Thomas ;

Mackay, Charles R. ;

Mansur, Daniel ;

Caballero, Mauricio T. ;

Marzec, Jacqui ;

Li, Jianying ;

Wang, Xuting ;

Bell, Douglas ;

Polack, Fernando P. ;

Kleeberger, Steven R. ;

Stein, Renato T. ;

Ramirez Vinolo, Marco Aurelio ;

Duarte de Souza, Ana Paula .

NATURE COMMUNICATIONS, 2019, 10 (1)

[4] Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation [J].

Arpaia, Nicholas ;

Campbell, Clarissa ;

Fan, Xiying ;

Dikiy, Stanislav ;

van der Veeken, Joris ;

deRoos, Paul ;

Liu, Hui ;

Cross, Justin R. ;

Pfeffer, Klaus ;

Coffer, Paul J. ;

Rudensky, Alexander Y. .

NATURE, 2013, 504 (7480) :451-+

[5] Protective and aggressive bacterial subsets and metabolites modify hepatobiliary inflammation and fibrosis in a murine model of PSC [J].

Awoniyi, Muyiwa ;

Wang, Jeremy ;

Ngo, Billy ;

Meadows, Vik ;

Tam, Jason ;

Viswanathan, Amba ;

Lai, Yunjia ;

Montgomery, Stephanie ;

Farmer, Morgan ;

Kummen, Martin ;

Thingholm, Louise ;

Schramm, Christoph ;

Bang, Corinna ;

Franke, Andre ;

Lu, Kun ;

Zhou, Huiping ;

Bajaj, Jasmohan S. ;

Hylemon, Phillip B. ;

Ting, Jenny ;

Popov, Yury, V ;

Hov, Johannes Roksund ;

Francis, Heather L. ;

Sartor, Ryan Balfour .

GUT, 2023, 72 (04) :671-685

[6] Memory CD8+ T Cells Balance Pro- and Anti-inflammatory Activity by Reprogramming Cellular Acetate Handling at Sites of Infection [J].

Balmer, Maria L. ;

Ma, Eric H. ;

Thompson, Andrew J. ;

Epple, Raja ;

Unterstab, Gunhild ;

Loetscher, Jonas ;

Dehio, Philippe ;

Schuerch, Christian M. ;

Warncke, Jan D. ;

Perrin, Gaelle ;

Woischnig, Anne-Kathrin ;

Graehlert, Jasmin ;

Loeliger, Jordan ;

Assmann, Nadine ;

Bantug, Glenn R. ;

Schaeren, Olivier P. ;

Khanna, Nina ;

Egli, Adrian ;

Bubendorf, Lukas ;

Rentsch, Katharina ;

Hapfelmeier, Siegfried ;

Jones, Russell G. ;

Hess, Christoph .

CELL METABOLISM, 2020, 32 (03) :457-+

[7] Memory CD8+ T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function [J].

Balmer, Maria L. ;

Ma, Eric H. ;

Bantug, Glenn R. ;

Grahlert, Jasmin ;

Pfister, Simona ;

Glatter, Timo ;

Jauch, Annaise ;

Dimeloe, Sarah ;

Slack, Emma ;

Dehio, Philippe ;

Krzyzaniak, Magdalena A. ;

King, Carolyn G. ;

Burgener, Anne-Valerie ;

Fischer, Marco ;

Develioglu, Leyla ;

Belle, Reka ;

Recher, Mike ;

Bonilla, Weldy V. ;

Macpherson, Andrew J. ;

Hapfelmeier, Siegfried ;

Jones, Russell G. ;

Hess, Christoph .

IMMUNITY, 2016, 44 (06) :1312-1324

[8] IFNγ Induces DNA Methylation-Silenced GPR109A Expression via pSTAT1/p300 and H3K18 Acetylation in Colon Cancer [J].

Bardhan, Kankana ;

Paschall, Amy V. ;

Yang, Dafeng ;

Chen, May R. ;

Simon, Priscilla S. ;

Bhutia, Yangzom D. ;

Martin, Pamela M. ;

Thangaraju, Muthusamy ;

Browning, Darren D. ;

Ganapathy, Vadivel ;

Heaton, Christopher M. ;

Gu, Keni ;

Lee, Jeffrey R. ;

Liu, Kebin .

CANCER IMMUNOLOGY RESEARCH, 2015, 3 (07) :795-805

[9] Effects of Resistant Starch on Symptoms, Fecal Markers, and Gut Microbiota in Parkinson's Disease - The RESISTA-PD Trial [J].

Becker, Anouck ;

Schmartz, Georges Pierre ;

Groeger, Laura ;

Grammes, Nadja ;

Galata, Valentina ;

Philippeit, Hannah ;

Weiland, Jacqueline ;

Ludwig, Nicole ;

Meese, Eckart ;

Tierling, Sascha ;

Walter, Jorn ;

Schwiertz, Andreas ;

Spiegel, Jorg ;

Wagenpfeil, Gudrun ;

Fassbender, Klaus ;

Keller, Andreas ;

Unger, Marcus M. .

GENOMICS PROTEOMICS & BIOINFORMATICS, 2022, 20 (02) :274-287

[10] The challenges of primary biliary cholangitis: What is new and what needs to be done [J].

Benedetta, Terziroli Beretta-Piccoli ;

Mieli-Vergani, Giorgina ;

Vergani, Diego ;

Vierling, John M. ;

Adams, David ;

Alpini, Gianfranco ;

Banales, Jesus M. ;

Beuers, Ulrich ;

Bjornsson, Einar ;

Bowlus, Christopher ;

Carbone, Marco ;

Chazouilleres, Olivier ;

Dalekos, George ;

De Gottardi, Andrea ;

Harada, Kenichi ;

Hirschfield, Gideon ;

Invernizzi, Pietro ;

Jones, David ;

Krawitt, Edward ;

Lanzavecchia, Antonio ;

Lian, Zhe-Xiong ;

Ma, Xiong ;

Manns, Michael ;

Mavilio, Domenico ;

Quigley, Eamon M. M. ;

Sallusto, Federica ;

Shimoda, Shinji ;

Strazzabosco, Mario ;

Swain, Mark ;

Tanaka, Atsushi ;

Trauner, Michael ;

Tsuneyama, Koichi ;

Zigmond, Ehud ;

Gershwin, M. Eric .

JOURNAL OF AUTOIMMUNITY, 2019, 105

← 1 2 3 4 5 6 7 8 9 10 →