Red Blood Cell Metabolism In Vivo and In Vitro

被引：51

作者：

D'Alessandro, Angelo ^{[1
]}

Anastasiadi, Alkmini T. ^{[2
,3
,4
]}

Tzounakas, Vassilis L. ^{[4
]}

Nemkov, Travis ^{[1
]}

Reisz, Julie A. ^{[1
]}

Kriebardis, Anastsios G. ^{[2
,3
]}

Zimring, James C. ^{[5
]}

Spitalnik, Steven L. ^{[6
]}

Busch, Michael P. ^{[7
]}

机构：

[1] Univ Colorado, Dept Biochem & Mol Genet, Anschutz Med Campus, Aurora, CO 80045 USA

[2] Univ West Attica UniWA, Lab Reliabil, Egaleo 12243, Greece

[3] Univ West Attica UniWA, Sch Hlth & Caring Sci, Dept Biomed Sci, Qual Control Lab Hematol HemQcR, Egaleo 12243, Greece

[4] Univ Patras, Sch Med, Dept Biochem, Patras 26504, Greece

[5] Univ Virginia, Dept Pathol, Charlottesville, VA 22903 USA

[6] Columbia Univ, Irving Med Ctr, New York, NY 10032 USA

[7] Vitalant Res Inst, San Francisco, CA 94105 USA

来源：

METABOLITES | 2023年 / 13卷 / 07期

关键词：

red blood cell; erythrocyte; transfusion medicine; storage lesion; hemolysis; spleen; mitochondria; iron; hematology; CHRONIC KIDNEY-DISEASE; OXIDATIVE STRESS; NITRIC-OXIDE; GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENT; MITOCHONDRIAL RETENTION; O-METHYLTRANSFERASE; REVEALS DIFFERENCES; ROUTINE STORAGE; DOWN-SYNDROME; MEMBRANE;

D O I：

10.3390/metabo13070793

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Red blood cells (RBC) are the most abundant cell in the human body, with a central role in oxygen transport and its delivery to tissues. However, omics technologies recently revealed the unanticipated complexity of the RBC proteome and metabolome, paving the way for a reinterpretation of the mechanisms by which RBC metabolism regulates systems biology beyond oxygen transport. The new data and analytical tools also informed the dissection of the changes that RBCs undergo during refrigerated storage under blood bank conditions, a logistic necessity that makes >100 million units available for life-saving transfusions every year worldwide. In this narrative review, we summarize the last decade of advances in the field of RBC metabolism in vivo and in the blood bank in vitro, a narrative largely influenced by the authors' own journeys in this field. We hope that this review will stimulate further research in this interesting and medically important area or, at least, serve as a testament to our fascination with this simple, yet complex, cell.

引用

页数：20

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