Cu-Catalyzed C(sp3) Amination of Unactivated Secondary Alkyl Iodides Promoted by Diaryliodonium Salts

被引：13

作者：

Lv, Xin-Yang ^{[1
,2
]}

Martin, Ruben ^{[1
,3
]}

机构：

[1] Barcelona Inst Sci & Technol, Inst Chem Res Catalonia ICIQ, Tarragona 43007, Spain

[2] Univ Rovira & Virgili, Dept Quim Analit & Quim Organ, Tarragona 43007, Spain

[3] ICREA, Barcelona 08010, Spain

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 20期

关键词：

N-ALKYLATION; COPPER; PALLADIUM; HALIDES; POTENT;

D O I：

10.1021/acs.orglett.3c01216

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we describe the development of a copper-catalyzedC-(sp(3)) amination of unactivated secondary alkyl iodidesmediatedby diaryliodonium salts. Our protocol is enabled by the intermediacyof aryl radical species that undergo halogen atom transfer prior tointerfacing with copper catalysts, thus setting the basis for a C-Nbond formation at sp(3)-hybridized carbons. The method ischaracterized by its mild reaction conditions, excellent regioselectivity,and wide substrate scope.

引用

页码：3750 / 3754

页数：5

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