Prognostic significance of the cachexia index in patients with stage I-III colorectal cancer who underwent laparoscopic surgery

被引:13
作者
Kamada, Teppei [1 ,2 ]
Haruki, Koichiro [2 ]
Nakashima, Keigo [1 ,2 ]
Takahashi, Junji [1 ,2 ]
Nakaseko, Yuichi [1 ,2 ]
Suzuki, Norihiko [1 ]
Ohdaira, Hironori [1 ]
Eto, Ken [2 ]
Ikegami, Toru [2 ]
Suzuki, Yutaka [1 ]
机构
[1] Int Univ Hlth & Welf Hosp, Dept Surg, 537-3 Iguchi, Nasushiobara, Tochigi 3292763, Japan
[2] Jikei Univ, Dept Surg, Sch Med, 3-25-8 Nishi Shimbashi,Minato Ku, Tokyo 1058461, Japan
关键词
Cachexia index; Cancer cachexia; Colorectal cancer; Survival; CELL LUNG-CANCER; DIAGNOSTIC-CRITERIA; OUTCOMES; CLASSIFICATION; THERAPY; TUMOR;
D O I
10.1007/s00595-023-02646-4
中图分类号
R61 [外科手术学];
学科分类号
摘要
PurposeThe prognostic significance of the cachexia index, a novel biomarker of cancer cachexia, remains unclear in colorectal cancer; we, therefore, evaluated this relationship.Methods This retrospective cohort study included 306 patients with stage I-III colorectal cancer who underwent R0 resection between April 2010 and March 2020. The cachexia index was calculated as (skeletal muscle index [cm(2)/m(2)] x serum albumin level [g/dL])/neutrophil-to-lymphocyte ratio. The overall and disease-free survival rates were analyzed using a Cox proportional hazards model.Results A low cachexia index was found in 94 patients. This group had significantly lower disease-free survival and overall survival than the high-cachexia index group (5-year survival, 86.3% vs. 63.1%, p < 0.01; 87.9% vs. 67.2%, p < 0.01). Multivariate analyses showed that T3 or T4 (hazard ratio [HR]: 2.56; 95% confidence interval CI 1.04-6.25, p = 0.039), stage III (HR: 3.77; 95% CI 1.79-7.93, p < 0.01), and a low cachexia index (HR: 2.27; 95% CI 1.31-3.90, p = 0.003) were significant independent predictors of the disease-free survival. CA19-9 >= 37.0 ng/mL (HR: 2.68; 95% CI: 1.37-5.24, p = 0.004), stage III (HR: 2.57; 95% CI 1.34-4.92, p = 0.004), and a low cachexia index (HR: 2.35; 95% CI 1.31-4.21, p = 0.004) were significant independent predictors of the overall survival.Conclusion A low cachexia index might be a long-term prognostic factor of colorectal cancer.
引用
收藏
页码:1064 / 1072
页数:9
相关论文
共 32 条
[1]   The relationship between computed tomography derived skeletal muscle index, psoas muscle index and clinical outcomes in patients with operable colorectal cancer [J].
Abbass, Tanvir ;
Ho, Yeung Timothy Tsz ;
Horgan, Paul G. ;
Dolan, Ross D. ;
McMillan, Donald C. .
CLINICAL NUTRITION ESPEN, 2020, 39 :104-113
[2]   Cancer cachexia: understanding the molecular basis [J].
Argiles, Josep M. ;
Busquets, Silvia ;
Stemmler, Britta ;
Lopez-Soriano, Francisco J. .
NATURE REVIEWS CANCER, 2014, 14 (11) :754-762
[3]  
[Anonymous], 2020, CA Cancer J Clin, V70, P313, DOI [10.3322/caac.21492, 10.3322/caac.21609]
[4]   Proteolysis inducing factor is expressed in tumours of patients with gastrointestinal cancers and correlates with weight loss [J].
Cabal-Manzano, R ;
Bhargava, P ;
Torres-Duarte, A ;
Marshall, J ;
Bhargava, P ;
Wainer, IW .
BRITISH JOURNAL OF CANCER, 2001, 84 (12) :1599-1601
[5]   Tumor and its microenvironment: A synergistic interplay [J].
Catalano, Veronica ;
Turdo, Alice ;
Di Franco, Simone ;
Dieli, Francesco ;
Todaro, Matilde ;
Stassi, Giorgio .
SEMINARS IN CANCER BIOLOGY, 2013, 23 (06) :522-532
[6]   Clinical results in cachexia therapeutics [J].
Crawford, Jeffrey .
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2016, 19 (03) :199-204
[7]   Primary tumor sidedness and benefit from FOLFOXIRI plus bevacizumab as initial therapy for metastatic colorectal cancer. Retrospective analysis of the TRIBE trial by GONO [J].
Cremolini, C. ;
Antoniotti, C. ;
Lonardi, S. ;
Bergamo, F. ;
Cortesi, E. ;
Tomasello, G. ;
Moretto, R. ;
Ronzoni, M. ;
Racca, P. ;
Loupakis, F. ;
Zaniboni, A. ;
Tonini, G. ;
Buonadonna, A. ;
Marmorino, F. ;
Allegrini, G. ;
Granetto, C. ;
Masi, G. ;
Zagonel, V. ;
Sensi, E. ;
Fontanini, G. ;
Boni, L. ;
Falcone, A. .
ANNALS OF ONCOLOGY, 2018, 29 (07) :1528-1534
[8]   Prognostic value of muscle atrophy in cirrhosis using psoas muscle thickness on computed tomography [J].
Durand, Franois ;
Buyse, Sophie ;
Francoz, Claire ;
Laouenan, Cedric ;
Bruno, Onorina ;
Belghiti, Jacques ;
Moreau, Richard ;
Vilgrain, Valerie ;
Valla, Dominique .
JOURNAL OF HEPATOLOGY, 2014, 60 (06) :1151-1157
[9]   Definition and classification of cancer cachexia: an international consensus [J].
Fearon, Kenneth ;
Strasser, Florian ;
Anker, Stefan D. ;
Bosaeus, Ingvar ;
Bruera, Eduardo ;
Fainsinger, Robin L. ;
Jatoi, Aminah ;
Loprinzi, Charles ;
MacDonald, Neil ;
Mantovani, Giovanni ;
Davis, Mellar ;
Muscaritoli, Maurizio ;
Ottery, Faith ;
Radbruch, Lukas ;
Ravasco, Paula ;
Walsh, Declan ;
Wilcock, Andrew ;
Kaasa, Stein ;
Baracos, Vickie E. .
LANCET ONCOLOGY, 2011, 12 (05) :489-495
[10]   Evaluation of cumulative prognostic scores based on the systemic inflammatory response in patients with inoperable non-small-cell lung cancer [J].
Forrest, LM ;
McMillan, DC ;
McArdle, CS ;
Angerson, WJ ;
Dunlop, DJ .
BRITISH JOURNAL OF CANCER, 2003, 89 (06) :1028-1030