Differences in Histological Subtypes of Invasive Lobular Breast Carcinoma According to Immunohistochemical Molecular Classification

被引:4
|
作者
Ilic, Ivan [1 ]
Cvetkovic, Jana [2 ]
Ilic, Ratko [1 ]
Cvetkovic, Ljubisa [2 ]
Milicevic, Aleksandar [1 ]
Todorovic, Stefan [3 ]
Randelovic, Pavle [4 ]
机构
[1] Univ Nis, Univ Clin Ctr Nis, Fac Med, Ctr Pathol & Pathol Anat, Nish 18000, Serbia
[2] Gen Hosp Leskovac, Dept Pathol, Leskovac 16000, Serbia
[3] Univ Clin Ctr Nis, Clin Neurol, Nish 18000, Serbia
[4] Univ Nis, Fac Med, Dept Physiol, Nish 18000, Serbia
关键词
invasive lobular carcinoma; estrogen and progesterone receptors; immunohistochemistry; molecular subtypes; triple-negative breast cancer; CANCER; STAGE; MAMMOGRAPHY; ESTROGEN;
D O I
10.3390/diagnostics14060660
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The technical complexity of gene expression profiling in routine practice has necessitated the use of surrogate molecular classification of breast cancer, based on immunohistochemical analyses. Background and objectives: The aim of this study was to compare the differences between histological and molecular subtypes of invasive lobular carcinoma (ILC) of the breast, in order to be able to predict the behavior and prognosis of the disease, as well as to effectively determine therapy. Material and Methods: This study included 263 cases of breast ILC diagnosed over a seven-year period. The diagnosis of invasive lobular carcinoma is based on the characteristic growth pattern and phenotype of cancer cells with the respective subtypes: classic, alveolar, solid, tubulolobular, pleomorphic and mixed lobular type. The examined cases were divided into five groups according to molecular classification based on the expression of ER, PR, HER2 and Ki67 immunohistochemical markers. Results: It was found that the pleomorphic subtype occurred statistically significantly less often as the luminal A subtype compared to others (p = 0.00027), and the HER2-enriched subtype occurred statistically significantly more often in the pT4 stage (p = 0.024). Conclusions: The results of this study significantly singled out the luminal A subtype, and among them classic ILC, as the subtype with the most favorable expression ratio of the investigated predictive/prognostic immunohistochemical markers.
引用
收藏
页数:12
相关论文
共 50 条
  • [1] The prognosis of invasive ductal carcinoma, lobular carcinoma and mixed ductal and lobular carcinoma according to molecular subtypes of the breast
    Hengqiang Zhao
    Breast Cancer, 2021, 28 (1) : 187 - 195
  • [2] The prognosis of invasive ductal carcinoma, lobular carcinoma and mixed ductal and lobular carcinoma according to molecular subtypes of the breast
    Zhao, Hengqiang
    BREAST CANCER, 2021, 28 (01) : 187 - 195
  • [3] INVASIVE LOBULAR CARCINOMA OF THE BREAST: CYTOMETRIC AND IMMUNOHISTOCHEMICAL CHARACTERISTICS OF 96 CASES
    Skotnicki, Piotr
    Rys, Janusz
    Blecharz, Pawel
    Reinfuss, Marian
    Jakubowicz, Jerzy
    Ambicka, Aleksandra
    Kruczak, Anna
    Lackowska, Bozena
    POLISH JOURNAL OF PATHOLOGY, 2012, 63 (02) : 112 - 120
  • [4] Molecular Classification of Lobular Carcinoma of the Breast
    Fu, Denggang
    Zuo, Qi
    Huang, Qi
    Su, Li
    Ring, Huijun Z.
    Ring, Brian Z.
    SCIENTIFIC REPORTS, 2017, 7
  • [5] A comparison of the clinical outcomes of patients with invasive lobular carcinoma and invasive ductal carcinoma of the breast according to molecular subtype in a Korean population
    Lim, Seung Taek
    Yu, Jong Han
    Park, Heung Kyu
    Moon, Byung In
    Ko, Byung Kyun
    Suh, Young Jin
    WORLD JOURNAL OF SURGICAL ONCOLOGY, 2014, 12
  • [6] Correlations Between Ultrasonographic Findings of Invasive Lobular Carcinoma of the Breast and Intrinsic Subtypes
    Wen, Xin
    Yu, Yingjiao
    Yu, Xiwen
    Cheng, Wen
    Wang, Zhuozhong
    Liu, Lin
    Zhang, Lei
    Qin, Ling
    Tian, Jiawei
    ULTRASCHALL IN DER MEDIZIN, 2019, 40 (06): : 764 - 770
  • [7] Immunohistochemical features of multifocal and multicentric lobular breast carcinoma
    Ilic, Ivan R.
    Petrovic, Aleksandar
    Zivkovic, Vesna V.
    Randjelovic, Pavle J.
    Stojanovic, Nikola M.
    Radulovic, Niko S.
    Randjelovic, Dusica
    Ilic, Ratko S.
    ADVANCES IN MEDICAL SCIENCES, 2017, 62 (01): : 78 - 82
  • [8] Gastrointestinal Tract Metastases of Invasive Lobular Carcinoma of the Breast: An Immunohistochemical Survey Algorithm
    Zengel, Baha
    Cavdar, Demet
    Ozdemir, Ozlem
    Tasli, Funda
    Karatas, Murat
    Simsek, Cenk
    Uslu, Adam
    EUROPEAN JOURNAL OF BREAST HEALTH, 2022, 18 (04) : 375 - 380
  • [9] Differences between invasive lobular and invasive ductal carcinoma of the breast: results and therapeutic implications
    Barroso-Sousa, Romualdo
    Metzger-Filho, Otto
    THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2016, 8 (04) : 261 - 266
  • [10] DIFFERENT MOLECULAR SUBTYPES OF BREAST INVASIVE DUCTAL CARCINOMA
    Zheng, L. J.
    Yang, D.
    Sun, L. J.
    Li, S. S.
    Wang, J. Y.
    Ye, S. C.
    JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, 2018, 32 (03) : 553 - 563