Insights into the Relationship between Periodontitis and Systemic Sclerosis Based on the New Periodontitis Classification (2018): A Cross-Sectional Study

被引:2
作者
Ciurea, Andreea [1 ,2 ]
Stanomir, Alina [1 ]
Surlin, Petra [3 ]
Micu, Iulia Cristina [1 ]
Pamfil, Cristina [2 ,4 ]
Leucuta, Daniel Corneliu [5 ]
Rednic, Simona [2 ,4 ]
Rasperini, Giulio [6 ]
Soanca, Andrada [1 ,2 ]
Tigu, Adrian Bogdan [7 ]
Roman, Alexandra [1 ,2 ]
Picos, Andrei [8 ]
Delean, Ada Gabriela [9 ]
机构
[1] Iuliu Hatieganu Univ Med & Pharm, Fac Dent Med, Dept Periodontol, Cluj Napoca 400012, Romania
[2] Emergency Cty Clin Hosp Cluj, Cluj Napoca 400006, Romania
[3] Univ Med & Pharm Craiova, Fac Dent Med, Dept Periodontol, Craiova 200349, Romania
[4] Iuliu Hatieganu Univ Med & Pharm, Fac Med, Dept Rheumatol, Cluj Napoca 400006, Romania
[5] Iuliu Hatieganu Univ Med & Pharm, Fac Med, Dept Med Informat & Biostat, Cluj Napoca 400347, Romania
[6] Univ Milan, Fdn IRCCS Ca Granda Policlin, Dept Biomed Surg & Dent Sci, I-20122 Milan, Italy
[7] Iuliu Hatieganu Univ Med & Pharm, MedFuture Res Ctr Adv Med, Cluj Napoca 400347, Romania
[8] Iuliu Hatieganu Univ Med & Pharm, Fac Dent Med, Dept Prevent Dent Med, Cluj Napoca 400083, Romania
[9] Iuliu Hatieganu Univ Med & Pharm, Fac Dent Med, Dept Odontol, Cluj Napoca 400001, Romania
关键词
systemic scleroderma; periodontitis; inflammation; biomarker; GINGIVAL CREVICULAR FLUID; PERI-IMPLANT DISEASES; CONSENSUS REPORT; WORLD WORKSHOP; ORAL-HEALTH; CALPROTECTIN; ASSOCIATION; LIPOPOLYSACCHARIDE; MANIFESTATIONS; INFLAMMATION;
D O I
10.3390/diagnostics14050540
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
(1) Background: This study aimed to assess the periodontitis burden in systemic sclerosis patients and the possible association between them, and the degree to which some potential risk factors and two potential diagnostic biomarkers may account for this association. (2) Methods: This cross-sectional study included a test group (systemic sclerosis patients) and a control group (non-systemic sclerosis patients). Both groups benefited from medical, periodontal examination and saliva sampling to determine the salivary flow rate and two inflammatory biomarkers (calprotectin, psoriasin). A systemic sclerosis severity scale was established. (3) Results: In the studied groups, comparable periodontitis rates of 88.68% and 85.85%, respectively, were identified. There were no significant differences in the severity of periodontitis among different systemic sclerosis severity, or in the positivity for anti-centromere and anti-SCL70 antibodies. Musculoskeletal lesions were significantly more common in stage III/IV periodontitis (n = 33, 86.84%) than in those in stage I/II (n = 1, 100%, and n = 3, 37.5%, respectively) (p = 0.007). Comparable levels of the inflammatory mediators were displayed by the two groups. There were no significant differences in calprotectin and psoriasin levels between diffuse and limited forms of systemic sclerosis. (4) Conclusions: Within the limitations of the current study, no associations between systemic sclerosis and periodontitis, or between their risk factors, could be proven.
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页数:16
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