A Study of the Properties of Scaffolds for Bone Regeneration Modified with Gel-like Coatings of Chitosan and Folic Acid

被引:2
作者
Bandzerewicz, Aleksandra [1 ]
Godzieba, Kamila [1 ]
Wierzchowski, Kamil [2 ]
Pilarek, Maciej [2 ]
Gadomska-Gajadhur, Agnieszka [1 ]
机构
[1] Warsaw Univ Technol, Fac Chem, PL-00664 Warsaw, Poland
[2] Warsaw Univ Technol, Fac Chem & Proc Engn, PL-00645 Warsaw, Poland
关键词
tissue engineering; scaffold; polylactide; chitosan; folic acid; bone regeneration; polymer gelling; gel coatings; TISSUE; POLYLACTIDE;
D O I
10.3390/gels9100773
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
The research has been conducted to obtain scaffolds for cancellous bone regeneration. Polylactide scaffolds were made by the phase inversion method with a freeze-extraction variant, including gelling polylactide in its non-solvent. Substitutes made of polylactide are hydrophobic, which limits cell adhesion. For this reason, the scaffolds were modified using chitosan and folic acid by forming gel-like coatings on the surface. The modification aimed to improve the material's surface properties and increase cell adhesion. Analyses of obtained scaffolds confirmed the effectiveness of performed changes. The presence of chitosan and folic acid was confirmed in the modified scaffolds, while all scaffolds retained high open porosity, which is essential for proper cell growth inside the scaffold and the free flow of nutrients. Hydrostatic weighing showed that the scaffolds have high mass absorbability, allowing them to be saturated with biological fluids. There were also cytotoxicity tests performed on 24 h extracts of the materials obtained, which indicated a lack of cytotoxic effect.
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页数:14
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共 27 条
  • [1] Bone tissue engineering techniques, advances, and scaffolds for treatment of bone defects
    Alonzo, Matthew
    Primo, Fabian Alvarez
    Kumar, Shweta Anil
    Mudloff, Joel A.
    Dominguez, Erick
    Fregoso, Gisel
    Ortiz, Nick
    Weiss, William M.
    Joddar, Binata
    [J]. CURRENT OPINION IN BIOMEDICAL ENGINEERING, 2021, 17
  • [2] Recent advances in 3D-printed polylactide and polycaprolactone-based biomaterials for tissue engineering applications
    Arif, Zia Ullah
    Khalid, Muhammad Yasir
    Noroozi, Reza
    Sadeghianmaryan, Ali
    Jalalvand, Meisam
    Hossain, Mokarram
    [J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2022, 218 : 930 - 968
  • [3] Recent Advances in Biopolymeric Composite Materials for Tissue Engineering and Regenerative Medicines: A Review
    Aslam Khan, Muhammad Umar
    Abd Razak, Saiful Izwan
    Al Arjan, Wafa Shamsan
    Nazir, Samina
    Sahaya Anand, T. Joseph
    Mehboob, Hassan
    Amin, Rashid
    [J]. MOLECULES, 2021, 26 (03):
  • [4] Chitosan-based scaffolds as drug delivery systems in bone tissue engineering
    Bharathi, R.
    Ganesh, S. Shree
    Harini, G.
    Vatsala, Kumari
    Anushikaa, R.
    Aravind, S.
    Abinaya, S.
    Selvamurugan, N.
    [J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2022, 222 : 132 - 153
  • [5] Tissue engineering Approaches in the Design of Healthy and Pathological In Vitro Tissue Models
    Caddeo, Silvia
    Boffito, Monica
    Sartori, Susanna
    [J]. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2017, 5
  • [6] 3D Printing of Micro- and Nanoscale Bone Substitutes: A Review on Technical and Translational Perspectives
    Cheng, Lijia
    Suresh, Shoma K.
    He, Hongyan
    Rajput, Ritu Singh
    Feng, Qiyang
    Ramesh, Saravanan
    Wang, Yuzhuang
    Krishnan, Sasirekha
    Ostrovidov, Serge
    Camci-Unal, Gulden
    Ramalingam, Murugan
    [J]. INTERNATIONAL JOURNAL OF NANOMEDICINE, 2021, 16 : 4289 - 4319
  • [7] Collagen tissue treated with chitosan solutions in carbonic acid for improved biological prosthetic heart valves
    Gallyamov, Marat O.
    Chaschin, Ivan S.
    Khokhlova, Marina A.
    Grigorev, Timofey E.
    Bakuleva, Natalia P.
    Lyutova, Irina G.
    Kondratenko, Janna E.
    Badun, Gennadii A.
    Chernysheva, Maria G.
    Khokhlov, Alexei R.
    [J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2014, 37 : 127 - 140
  • [8] Processing of biomaterials for bone tissue engineering: State of the art
    Gautam, Gaurav
    Kumar, Sanjeev
    Kumar, Kamal
    [J]. MATERIALS TODAY-PROCEEDINGS, 2022, 50 : 2206 - 2217
  • [9] New emerging trends in synthetic biodegradable polymers - Polylactide: A critique
    Gupta, A. P.
    Kumar, Vimal
    [J]. EUROPEAN POLYMER JOURNAL, 2007, 43 (10) : 4053 - 4074
  • [10] Chitosan based bioactive materials in tissue engineering applications-A review
    Islam, Md Minhajul
    Shahruzzaman, Md
    Biswas, Shanta
    Sakib, Md Nurus
    Rashid, Taslim Ur
    [J]. BIOACTIVE MATERIALS, 2020, 5 (01) : 164 - 183