Cell-Penetrating Peptide-Based Delivery of Macromolecular Drugs: Development, Strategies, and Progress

被引：37

作者：

Sun, Zhe ^{[1
]}

Huang, Jinhai ^{[1
]}

Fishelson, Zvi ^{[2
]}

Wang, Chenhui ^{[3
]}

Zhang, Sihe ^{[3
]}

机构：

[1] Tianjin Univ, Sch Life Sci, Tianjin 300072, Peoples R China

[2] Tel Aviv Univ, Fac Med, Dept Cell & Dev Biol, IL-69978 Tel Aviv, Israel

[3] Nankai Univ, Sch Med, Dept Cell Biol, Tianjin 300071, Peoples R China

来源：

BIOMEDICINES | 2023年 / 11卷 / 07期

关键词：

cell-penetrating peptide; macromolecular drug delivery; cellular uptake mechanism; biological barrier; optimized strategy; PROTEIN-KINASE-C; TOXIN TYPE-A; INTRACELLULAR DELIVERY; IN-VITRO; GENE DELIVERY; DOUBLE-BLIND; OLIGONUCLEOTIDE DELIVERY; ANTENNAPEDIA HOMEODOMAIN; P53; UBIQUITINATION; ENDOSOMAL ESCAPE;

D O I：

10.3390/biomedicines11071971

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cell-penetrating peptides (CPPs), developed for more than 30 years, are still being extensively studied due to their excellent delivery performance. Compared with other delivery vehicles, CPPs hold promise for delivering different types of drugs. Here, we review the development process of CPPs and summarize the composition and classification of the CPP-based delivery systems, cellular uptake mechanisms, influencing factors, and biological barriers. We also summarize the optimization routes of CPP-based macromolecular drug delivery from stability and targeting perspectives. Strategies for enhanced endosomal escape, which prolong its half-life in blood, improved targeting efficiency and stimuli-responsive design are comprehensively summarized for CPP-based macromolecule delivery. Finally, after concluding the clinical trials of CPP-based drug delivery systems, we extracted the necessary conditions for a successful CPP-based delivery system. This review provides the latest framework for the CPP-based delivery of macromolecular drugs and summarizes the optimized strategies to improve delivery efficiency.

引用

页数：29

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