Simvastatin attenuates inflammatory process on LPS-induced acute lung injury in mice

被引：5

作者：

Viegas Haute, Gabriela ^{[1
]}

Luft, Carolina ^{[1
,2
]}

Pedrazza, Leonardo ^{[1
]}

Luana Antunes, Gessica ^{[1
]}

Silveira, Josiane ^{[3
]}

de Souza Basso, Bruno ^{[1
]}

Schneider Levorse, Vitor Giancarlo ^{[1
]}

Scherer Bastos, Matheus ^{[1
]}

Melo, Denizar ^{[1
]}

Fernanda Rodrigues, Ketlin ^{[1
]}

Claudia Garcia, Maria ^{[1
]}

Severo da Costa, Mariana ^{[1
]}

Strassburger Matzenbacher, Lucas ^{[1
]}

Benvenutti Kaiber, Daniela ^{[1
]}

Fagundes Donadio, Marcio Vinicius ^{[1
,5
]}

Gracia-Sancho, Jordi ^{[4
,6
]}

Rodrigues de Oliveira, Jarbas ^{[1
]}

机构：

[1] Pontif Catholic Univ Rio Grande do Sul PUCRS, Lab Cellular Biophys & Inflammat, Porto Alegre, Brazil

[2] Brock Univ, Dept Psychol, St Catharines, ON, Canada

[3] Univ Fed Rio Grande Do Sul, Dept Biochem, Neuroprotect & Neurometab Dis Lab, Wyses Lab,ICBS, Porto Alegre, RS, Brazil

[4] Hosp Clin Barcelona, Barcelona Hepat Hemodynam Lab, IDIBAPS, CIBEREHD, Barcelona, Spain

[5] Univ Int Catalunya UIC, Dept Physiotherapy, Barcelona, Spain

[6] Univ Bern, Dept Clin Res, Hepatol, Bern, Switzerland

来源：

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY | 2023年 / 309卷

关键词：

Inflammation; Neutrophils; Macrophages; Cytokines; Acute lung injury; Simvastatin; RESPIRATORY-DISTRESS-SYNDROME; C-REACTIVE PROTEIN; MECHANICAL VENTILATION; RHEUMATOID-ARTHRITIS; NECROSIS-FACTOR; STATINS; THERAPY; SEPSIS; ROSUVASTATIN; DYSFUNCTION;

D O I：

10.1016/j.resp.2022.104002

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Acute lung injury (ALI) is a disease of high prevalence and is characterized by the excessive production of inflammatory mediators in the lungs of people sick. Inflammation is the major characteristic of ALI and studies report that inhibition of inflammatory cytokines could be an alternative treatment. Statins such as Simvastatin (SV) are known to their use for cholesterol reduction but also for inflammatory and immunoregulatory processes. In this study, we evaluated the effects of SV on LPS-induced alveolar macrophages and in ALI mice model. Our study has demonstrated the protective effects of SV on LPS-activated alveolar macrophages RAW 264.7 and LPSinduced ALI in mice. SV treatment significantly inhibited the alveolar macrophages activation by decreasing the iNOS, IL-1 beta, and IL-6 gene expression in vitro and in vivo. The treatment also decreased the inflammatory cells migration and the cytokines gene expression. Our findings suggest that SV can act as an anti-inflammatory agent for acute lung injury.

引用

页数：7

共 49 条

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