SARS-CoV-2 live virus neutralization after four COVID-19 vaccine doses in people with HIV receiving suppressive antiretroviral therapy

被引：11

作者：

Cheung, Peter R. ^{[1
,2
]}

Lapointe, Hope ^{[1
]}

Sang, Yurou ^{[2
]}

Ennis, Siobhan ^{[2
]}

Mwimanzi, Francis ^{[2
]}

Speckmaier, Sarah ^{[1
]}

Barad, Evan ^{[1
,2
]}

Dong, Winnie ^{[1
]}

Liang, Richard ^{[1
]}

Simons, Janet F. ^{[3
,4
]}

Lowe, Christopher G. ^{[3
,4
,5
]}

Romney, Marc J. ^{[3
,4
,5
]}

Brumme, Chanson ^{[1
,6
]}

Niikura, Masahiro A. ^{[2
]}

Brockman, Mark L. ^{[1
,2
,7
]}

Brumme, Zabrina ^{[1
,2
]}

机构：

[1] British Columbia Ctr Excellence HIV AIDS, Vancouver, BC, Canada

[2] Simon Fraser Univ, Fac Hlth Sci, Burnaby, BC, Canada

[3] Providence Healthcare, Dept Pathol & Lab Med, Renton, WA USA

[4] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada

[5] St Pauls Hosp, Div Med Microbiol & Virol, Vancouver, BC, Canada

[6] Univ British Columbia, Dept Med, Vancouver, BC, Canada

[7] Simon Fraser Univ, Dept Mol Biol & Biochem, Burnaby, BC, Canada

来源：

AIDS | 2023年 / 37卷 / 05期

基金：

加拿大创新基金会;

关键词：

COVID-19; fourth dose; HIV; hybrid immunity; Omicron BA; 5; Omicron BQ; 1; vaccine; viral neutralization;

D O I：

10.1097/QAD.0000000000003519

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Objective:Limited data exist regarding the immune benefits of fourth COVID-19 vaccine doses in people with HIV (PWH) receiving antiretroviral therapy (ART), particularly now that most have experienced a SARS-CoV-2 infection. We quantified wild-type, Omicron-BA.5 and Omicron-BQ.1-specific neutralization up to 1 month post-fourth COVID-19 vaccine dose in 63 (19 SARS-CoV-2-naive and 44 SARS-CoV-2-experienced) PWH.Design:A longitudinal observational cohort.Methods:Quantification of wild-type-, Omicron-BA.5, and Omicron-BQ.1-specific neutralization using live virus assays.Results:Participants received monovalent (44%) and bivalent (56%) mRNA fourth doses. In COVID-19-naive PWH, fourth doses enhanced wild-type and Omicron-BA.5-specific neutralization modestly above three-dose levels (P = 0.1). In COVID-19-experienced PWH, fourth doses enhanced wild-type specific neutralization modestly (P = 0.1) and BA.5-specific neutralization substantially (P = 0.002). Consistent with humoral benefits of 'hybrid' immunity, COVID-19-experienced PWH exhibited the highest neutralization post-fourth dose, wherein those with Omicron-era infections displayed higher wild-type specific (P = 0.04) but similar BA.5 and BQ.1-specific neutralization than those with pre-Omicron-era infections. Nevertheless, BA.5-specific neutralization was significantly below wild-type in everyone regardless of COVID-19 experience, with BQ.1-specific neutralization lower still (both P < 0.0001). In multivariable analyses, fourth dose valency did not affect neutralization magnitude. Rather, an mRNA-1273 fourth dose (versus a BNT162b2 one) was the strongest correlate of wild-type specific neutralization, while prior COVID-19, regardless of pandemic era, was the strongest correlate of BA.5 and BQ.1-specific neutralization post-fourth dose.Conclusion:Fourth COVID-19 vaccine doses, irrespective of valency, benefit PWH regardless of prior SARS-CoV-2 infection. Results support recommendations that all adults receive a fourth COVID-19 vaccine dose within 6 months of their third dose (or their most recent SARS-CoV-2 infection).

引用

页码：F11 / F18

页数：8

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