Using Optogenetics to Model Cellular Effects of Alzheimer's Disease

Across the world a dementia case is diagnosed every three seconds. Alzheimer's disease (AD) causes 50-60% of these cases. The most prominent theory for AD correlates the deposition of amyloid beta (A beta) with the onset of dementia. Whether A beta is causative remains unclear due to findings such as the recently approved drug Aducanumab showing effective clearance of A beta, but not improving cognition. New approaches for understanding A beta function, are therefore necessary. Here we discuss the application of optogenetic techniques to gain insight into AD. Optogenetics, or genetically encoded, light-dependent on/off switches, provides precise spatiotemporal control to regulate cellular dynamics. This precise control over protein expression and oligomerization or aggregation could provide a better understanding of the etiology of AD.