Bis(pinacoloto)diboron/4-Phenylpyridine System for One-Pot Photocatalyzed Borylation and Reduction of Aldehyde: Synthesis of Tavaborole in a Flow Reactor

被引:3
作者
Kumar, Kankanala Naveen
Mhate, Mouzma
Ravichandiran, Velayutham
Swain, Sharada Prasanna [1 ]
机构
[1] Natl Inst Pharmaceut Educ & Res Kolkata, Dept Med Chem, 168 Maniktala Main Rd, Kolkata 700054, India
来源
SYNTHESIS-STUTTGART | 2024年 / 56卷 / 04期
关键词
tavaborole; photocatalysis; flow chemistry; green chemistry; one-pot synthesis; HALOARENES;
D O I
10.1055/a-2169-6200
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A photocatalyzed one-pot borylation of haloarene and reduction of aldehyde by cocatalysis of bis(pinacoloto)diboron/4-phenylpyridine is reported. The reaction was carried out in a flow reactor by irradiating the reaction at 410 nm, with residence time of 10 minutes. The method was successfully applied for the synthesis of tavaborole in a single step with 81% yield.
引用
收藏
页码:573 / 576
页数:4
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