Conjugated Polymer Nanoparticles for Tumor Theranostics

被引：17

作者：

Li, Tianyu ^{[1
]}

Wu, Mengqi ^{[1
]}

Wei, Qidong ^{[1
]}

Xu, Dingshi ^{[1
]}

He, Xuehan ^{[2
]}

Wang, Jiasi ^{[1
]}

Wu, Jun ^{[3
,4
]}

Chen, Lei ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Biomed Engn, Shenzhen 518107, Peoples R China

[2] Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Shenzhen 518107, Peoples R China

[3] Hong Kong Univ Sci & Technol Guangzhou, Biosci & Biomed Engn Thrust, Guangzhou 511400, Peoples R China

[4] Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong 999077, Peoples R China

来源：

BIOMACROMOLECULES | 2023年 / 24卷 / 05期

关键词：

AGGREGATION-INDUCED EMISSION; CONTROLLED DRUG-DELIVERY; SEMICONDUCTING POLYMER; PHOTODYNAMIC THERAPY; ORGANIC NANOPARTICLES; CELL-DEATH; 800; NM; DOTS; FLUORESCENCE; BRIGHT;

D O I：

10.1021/acs.biomac.2c01446

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Water-dispersible conjugated polymer nanoparticles (CPNs) have demon-strated great capabilities in biological applications, such as in vitro cell/subcellular imaging and biosensing, or in vivo tissue imaging and disease treatment. In this review, we summarized the recent advances of CPNs used for tumor imaging and treatment during the past five years. CPNs with different structures, which have been applied to in vivo solid tumor imaging (fluorescence, photoacoustic, and dual-modal) and treatment (phototherapy, drug carriers, and synergistic therapy), are discussed in detail. We also demonstrated the potential of CPNs as cancer theranostic nanoplatforms. Finally, we discussed current challenges and outlooks in this field.

引用

页码：1943 / 1979

页数：37

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