miRNAs for testicular germ cell tumours: Contemporary indications for diagnosis, surveillance and follow-up

被引：4

作者：

Chavarriaga, Julian ^{[1
]}

Hamilton, Robert J. ^{[1
]}

机构：

[1] Princess Margaret Canc Ctr, Dept Surg, Div Urol, Toronto, ON, Canada

来源：

ANDROLOGY | 2023年 / 11卷 / 04期

关键词：

biomarkers; epigenetics; germ cell and embryonal; MicroRNA; neoplasms; non-seminomatous germ-cell tumours; seminoma; testicular cancer; SERUM BIOMARKERS; EXPRESSION; MICRORNA-371A-3P; MIR-371A-3P; MANAGEMENT; MICRORNAS; TERATOMA; PLASMA; FUTURE;

D O I：

10.1111/andr.13337

中图分类号：

R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

摘要：

Despite excellent outcomes with modern multidisciplinary care, clinicians caring for patients with testicular germ cell tumour (TGCTs) face clinical dilemmas across the spectrum of disease. Wrong treatment choices can lead to undertreatment or overtreatment of these young men. Unfortunately the currently available biomarkers alpha-fetoprotein and human chorionic gonadotropin, lack sufficient sensitivity and specificity to reliably aid in these clinical dilemmas. Thus, a sensitive and specific biomarker is desperately needed. Serum or plasma miRNA, in particular, miR-371a-3p, has shown great promise in discriminating the presence of TGCT and may represent a breakthrough for this disease. In this review, we discuss the potential role of miRNA across clinical states of TGCTs. We review their discovery, methods of assay, limitations and future potential.

引用

页码：628 / 633

页数：6

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