Flunixin meglumine tissue residues after intravenous administration in goats

被引：0

作者：

Giles, Claire B. ^{[1
]}

Ferdous, Farha ^{[1
]}

Halleran, Jennifer L. ^{[1
]}

Yeatts, Jim L. ^{[1
]}

Baynes, Ronald E. ^{[1
]}

Mzyk, Danielle A. ^{[1
]}

机构：

[1] North Carolina State Univ, Coll Vet Med, Dept Populat Hlth & Pathobiol, Raleigh, NC 27695 USA

来源：

FRONTIERS IN VETERINARY SCIENCE | 2024年 / 10卷

关键词：

flunixin; goat; residues; tolerance limit method; withdrawal interval; withdrawal time; PLASMA; MILK;

D O I：

10.3389/fvets.2023.1341779

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Background Flunixin is commonly used in goats in an extra-label manner, indicating a significant need to determine withdrawal intervals for edible tissues.Objective The objectives of the present study were to investigate the depletion of flunixin meglumine in various goat tissues, including the liver, kidney, fat, and muscle.Methods Twenty Boer goats were enrolled and administered an intravenous dose (2.2 mg/kg) of flunixin meglumine. Five animals were randomly euthanized at 24, 48, 72, or 96 h following dosing. All samples were analyzed via ultra-performance liquid chromatography coupled with mass spectrometry.Results The concentration of flunixin in all tissues declined rapidly, with the highest mean concentrations quantified in the kidney (0.137 +/- 0.062 mu g/g) and liver (0.077 +/- 0.029 mu g/g) tissues at 24 h.Conclusion Since any detection of flunixin residues at slaughter found in goat tissues is considered a violative residue, a conservative withdrawal interval of 17 days was calculated to ensure levels of flunixin fell below the regulatory limits of detection in liver, kidney, and muscle tissues.

引用

页数：7

共 14 条

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