Prognostic value of lncRNA LINC01018 in prostate cancer by regulating miR-182-5p (The role of LINC01018 in prostate cancer)

被引：2
作者：
Luo, Wentao [1 ]
Li, Tingting [1 ]
Song, Qiong [1 ]
Zhang, Lixiao [1 ]
Cao, Min [1 ,2 ]
机构：
[1] Hubei Univ Med, Sinopharm Dongfeng Gen Hosp, Dept Urol Androl, Shiyan, Hubei, Peoples R China
[2] Hubei Univ Med, sinopharm dongfeng Gen Hosp, Dept Urol Androl, 16,daling Rd, Shiyan 442008, Hubei, Peoples R China
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2024年 / 43卷 / 10期
关键词：
Prostate cancer; lncRNA LINC01018; overexpression; miR-182-5p; prognosis; HEPATOCELLULAR-CARCINOMA; CELL-PROLIFERATION; PROMOTES;
D O I：
10.1080/15257770.2023.2298408
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
LncRNAs are abnormally expressed in a variety of cancers and play unique roles in therapy. Based on this, the prognostic value of lncRNA LINC01018 in prostate cancer was discussed in this study. LINC01018 was underexpressed in prostate cancer tissues and cells, while miR-182-5p was elevated (***p < 0.001). Overexpression of LINC01018 may inhibit the progression of prostate cancer by targeting miR-182-5p. This study revealed that upregulated LINC01018 may prolong the overall survival of patients with prostate cancer (log-rank p = 0.042), and LINC01018 may become a prognostic biomarker for patients with prostate cancer, which brings a new direction for the treatment of patients.
引用
收藏
页码：1077 / 1089
页数：13
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