Hydroxyurea interaction with α7 nicotinic acetylcholine receptor can underlie its therapeutic efficacy upon COVID-19

In this paper the authors provide evidence that hydroxyurea (hydroxycarbamide) interacts with alpha 7 nicotinic acetylcholine receptor, exerts anti-inflammatory and pro-survival effect, prevents alpha 7 nicotinic receptor inter-action with angiotensin-converting enzyme-2 and stimulates IgM to IgG class switch upon immunization with SARS spike protein fragment 674-685. Hydroxyurea shifts immunoglobulin glycosylation profile to anti-inflammatory phenotype and prevents the appearance of anti-idiotypic alpha 7(179-190)-specific antibodies, as well as memory impairment. According to these results, interaction with alpha 7 nicotinic acetylcholine receptor may underlie positive therapeutic effects of hydroxyurea upon SARS-Cov-2 infection by interfering with virus penetration into the cell and providing anti-inflammatory and immunomodulatory effects.