O-GlcNAcylation: the sweet side of epigenetics

被引：6

作者：

Dupas, Thomas ^{[1
,2
]}

Lauzier, Benjamin ^{[1
,3
]}

Mcgraw, Serge ^{[1
,2
]}

机构：

[1] Ctr Hosp Univ St Justine Res Ctr, Montreal, PQ, Canada

[2] Univ Montreal, Dept Obstet & Gynecol, 2900 Blvd Edouard Montpetit, Montreal, PQ H3T 1J4, Canada

[3] Nantes Univ, Inst Thorax, CNRS, INSERM, F-44000 Nantes, France

来源：

EPIGENETICS & CHROMATIN | 2023年 / 16卷 / 01期

基金：

加拿大健康研究院;

关键词：

O-GlcNAcylation; Epigenetics; Histone modification; ACETYLGLUCOSAMINE TRANSFERASE OGT; GLCNAC TRANSFERASE; PROTEIN STABILITY; TET PROTEINS; GENE; CHROMATIN; METHYLTRANSFERASE; PHOSPHORYLATION; METHYLATION; CANCER;

D O I：

10.1186/s13072-023-00523-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Histones display a wide variety of post-translational modifications, including acetylation, methylation, and phosphorylation. These epigenetic modifications can influence chromatin structure and function without altering the DNA sequence. Histones can also undergo post-translational O-GlcNAcylation, a rather understudied modification that plays critical roles in almost all biological processes and is added and removed by O-linked N-acetylglucosamine transferase and O-GlcNAcase, respectively. This review provides a current overview of our knowledge of how O-GlcNAcylation impacts the histone code both directly and by regulating other chromatin modifying enzymes. This highlights the pivotal emerging role of O-GlcNAcylation as an essential epigenetic marker.

引用

页数：15

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