Genetic markers of chronic lymphocytic leukemia: a retrospective study of 312 patients from a reference center in Lebanon

被引：3

作者：

Ayoub, Georges ^{[1
]}

Sinan, Hassan ^{[2
]}

Kourie, Hampig Raphael ^{[3
]}

Kattan, Joseph ^{[3
]}

Nasr, Fadi ^{[3
]}

el Karak, Fadi ^{[3
]}

Wakim, Jad ^{[3
]}

Ghosn, Marwan ^{[3
]}

Chahine, Georges ^{[3
]}

Farra, Chantal ^{[4
]}

Chebly, Alain ^{[5
,6
]}

机构：

[1] St Joseph Univ Beirut, Fac Med, Beirut, Lebanon

[2] Amer Univ Beirut, Fac Med, Beirut, Lebanon

[3] Hotel Dieu France Univ Hosp, Dept Hematol Oncol, Beirut, Lebanon

[4] St Joseph Univ, Fac Med, Med Genet Unit, Beirut, Lebanon

[5] St Joseph Univ, Fac Med, Jacques Loiselet Ctr Med Genet & Genom CGGM, Beirut, Lebanon

[6] St Joseph Univ, Higher Inst Publ Hlth, Beirut, Lebanon

来源：

FUTURE ONCOLOGY | 2023年 / 19卷 / 29期

关键词：

biomarkers; chronic lymphocytic leukemia; CLL; cytogenetics; FISH; IGHV; karyotype; Lebanon; molecular diagnosis; MUTATIONAL STATUS; CHINESE; BIOMARKERS; IBRUTINIB; IG;

D O I：

10.2217/fon-2023-0535

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: Chronic lymphocytic leukemia (CLL) is a highly heterogenous hemopathy. Genetic stratification of CLL patients has important prognostic and therapeutic values - mainly immunoglobulin heavy chain variable region gene (IGHV) mutational status and the presence of cytogenetic abnormalities. The genetics of CLL in Lebanon is scarcely described in the literature. Patients & methods: In this work, we studied the genetic biomarkers of 312 Lebanese CLL patients. Results: Prominent IGHV genes were IGHV4-34, IGHV1-69 and IGHV3-30; and CLL #1 and #5 presented major subsets. Some similarities as well as major differences were highlighted when comparing our data with previously published data. Conclusion: The distribution of IGHV alleles in our series differed from previously described distributions, suggesting involvement of antigenic selection and regional variables in CLL pathogenesis.

引用

页码：1991 / 2002

页数：12

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