Genetic markers of chronic lymphocytic leukemia: a retrospective study of 312 patients from a reference center in Lebanon

被引：3

作者：

Ayoub, Georges ^{[1
]}

Sinan, Hassan ^{[2
]}

Kourie, Hampig Raphael ^{[3
]}

Kattan, Joseph ^{[3
]}

Nasr, Fadi ^{[3
]}

el Karak, Fadi ^{[3
]}

Wakim, Jad ^{[3
]}

Ghosn, Marwan ^{[3
]}

Chahine, Georges ^{[3
]}

Farra, Chantal ^{[4
]}

Chebly, Alain ^{[5
,6
]}

机构：

[1] St Joseph Univ Beirut, Fac Med, Beirut, Lebanon

[2] Amer Univ Beirut, Fac Med, Beirut, Lebanon

[3] Hotel Dieu France Univ Hosp, Dept Hematol Oncol, Beirut, Lebanon

[4] St Joseph Univ, Fac Med, Med Genet Unit, Beirut, Lebanon

[5] St Joseph Univ, Fac Med, Jacques Loiselet Ctr Med Genet & Genom CGGM, Beirut, Lebanon

[6] St Joseph Univ, Higher Inst Publ Hlth, Beirut, Lebanon

来源：

FUTURE ONCOLOGY | 2023年 / 19卷 / 29期

关键词：

biomarkers; chronic lymphocytic leukemia; CLL; cytogenetics; FISH; IGHV; karyotype; Lebanon; molecular diagnosis; MUTATIONAL STATUS; CHINESE; BIOMARKERS; IBRUTINIB; IG;

D O I：

10.2217/fon-2023-0535

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: Chronic lymphocytic leukemia (CLL) is a highly heterogenous hemopathy. Genetic stratification of CLL patients has important prognostic and therapeutic values - mainly immunoglobulin heavy chain variable region gene (IGHV) mutational status and the presence of cytogenetic abnormalities. The genetics of CLL in Lebanon is scarcely described in the literature. Patients & methods: In this work, we studied the genetic biomarkers of 312 Lebanese CLL patients. Results: Prominent IGHV genes were IGHV4-34, IGHV1-69 and IGHV3-30; and CLL #1 and #5 presented major subsets. Some similarities as well as major differences were highlighted when comparing our data with previously published data. Conclusion: The distribution of IGHV alleles in our series differed from previously described distributions, suggesting involvement of antigenic selection and regional variables in CLL pathogenesis.

引用

页码：1991 / 2002

页数：12

共 35 条

[1] Higher-order connections between stereotyped subsets: implications for improved patient classification in CLL
Agathangelidis, Andreas
Chatzidimitriou, Anastasia
Gemenetzi, Katerina
Giudicelli, Veronique
Karypidou, Maria
Plevova, Karla
Davis, Zadie
Yan, Xiao-Jie
Jeromin, Sabine
Schneider, Christof
Pedersen, Lone Bredo
Tschumper, Renee C.
Sutton, Lesley-Ann
Baliakas, Panagiotis
Scarfo, Lydia
van Gastel, Ellen J.
Armand, Marine
Tausch, Eugen
Biderman, Bella
Baer, Constance
Bagnara, Davide
Navarro, Alba
de Septenville, Anne Langlois
Guido, Valentina
Mitterbauer-Hohendanner, Gerlinde
Dimovski, Aleksandar
Brieghel, Christian
Lawless, Sarah
Meggendorfer, Manja
Brazdilova, Kamila
Ritgen, Matthias
Facco, Monica
Tresoldi, Cristina
Visentin, Andrea
Patriarca, Andrea
Catherwood, Mark
Bonello, Lisa
Sudarikov, Andrey
Vanura, Katrina
Roumelioti, Maria
Francova, Hana Skuhrova
Moysiadis, Theodoros
Veronese, Silvio
Giannopoulos, Krzysztof
Mansouri, Larry
Karan-Djurasevic, Teodora
Sandaltzopoulos, Raphael
Bodor, Csaba
Fais, Franco
Kater, Arnon
[J]. BLOOD, 2021, 137 (10) : 1365 - 1376
[2] Genetic and Clinical Characteristics of Korean Chronic Lymphocytic Leukemia Patients with High Frequencies of MYD88 Mutations
Ahn, Ari
Kim, Hoon Seok
Kim, Tong-Yoon
Lee, Jong-Mi
Kang, Dain
Yu, Haein
Lee, Chae Yeon
Kim, Yonggoo
Eom, Ki-Seong
Kim, Myungshin
[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (04)
[3] Alamyar E., 2012, Immunome Res., V08, DOI [DOI 10.4172/1745-7580.1000056, 10.4172/1745-7580.1000056]
[4] Alamyar Eltaf, 2012, Methods Mol Biol, V882, P569, DOI 10.1007/978-1-61779-842-9_32
[5] Recurrent mutations refine prognosis in chronic lymphocytic leukemia
Baliakas, P.
Hadzidimitriou, A.
Sutton, L-A
Rossi, D.
Minga, E.
Villamor, N.
Larrayoz, M.
Kminkova, J.
Agathangelidis, A.
Davis, Z.
Tausch, E.
Stalika, E.
Kantorova, B.
Mansouri, L.
Scarfo, L.
Cortese, D.
Navrkalova, V.
Rose-Zerilli, M. J. J.
Smedby, K. E.
Juliusson, G.
Anagnostopoulos, A.
Makris, A. M.
Navarro, A.
Delgado, J.
Oscier, D.
Belessi, C.
Stilgenbauer, S.
Ghia, P.
Pospisilova, S.
Gaidano, G.
Campo, E.
Strefford, J. C.
Stamatopoulos, K.
Rosenquist, R.
[J]. LEUKEMIA, 2015, 29 (02) : 329 - 336
[6] Pre-therapeutic assessment of chronic lymphocytic leukemia: which genetic assessment and why?
Baran-Marszak, Fanny
[J]. HEMATOLOGIE, 2020, 26 : 4 - 11
[7] Chronic lymphocytic leukaemia: from genetics to treatment
Bosch, Francesc
Dalla-Favera, Riccardo
[J]. NATURE REVIEWS CLINICAL ONCOLOGY, 2019, 16 (11) : 684 - 701
[8] IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis
Brochet, Xavier
Lefranc, Marie-Paule
Giudicelli, Veronique
[J]. NUCLEIC ACIDS RESEARCH, 2008, 36 : W503 - W508
[9] ARResT/AssignSubsets: a novel application for robust subclassification of chronic lymphocytic leukemia based on B cell receptor IG stereotypy
Bystry, Vojtech
Agathangelidis, Andreas
Bikos, Vasilis
Sutton, Lesley Ann
Baliakas, Panagiotis
Hadzidimitriou, Anastasia
Stamatopoulos, Kostas
Darzentas, Nikos
[J]. BIOINFORMATICS, 2015, 31 (23) : 3844 - 3846
[10] Clinicopathological features and outcome of chronic lymphocytic leukaemia in Chinese patients
Chan, Thomas Sau-Yan
Lee, Yuh-Shan
Del Giudice, Ilaria
Marinelli, Marilisa
Ilari, Caterina
Cafforio, Luciana
Guarini, Anna
Tan, Daryl
Phipps, Colin
Goh, Yeow-Tee
Hwang, William
Goh, Allan Zhi-Kai
Siu, Lisa Lai-Ping
Wu, Saliangi
Ha, Chun-Yin
Lin, Shek-Ying
Kwok, Chi-Hang
Lau, Chi-Kuen
Wong, Kit-Fai
Foa, Robin
Kwong, Yok-Lam
Tse, Eric
[J]. ONCOTARGET, 2017, 8 (15) : 25455 - 25468

← 1 2 3 4 →