Molecular Screening for Urothelial Cancer: How Close We Are?

被引：0

作者：

Michas, Athanasios ^{[1
,2
]}

Michas, Basileios ^{[1
]}

Tsitsibis, Anastasios ^{[1
]}

Tsoukalas, Nikolaos ^{[1
]}

机构：

[1] 401 Gen Army Hosp Athens, Dept Oncol, 401 Geniko Stratiotiko Nosokomeio Athenon, Athina, Greece

[2] 401 Gen Army Hosp Athens, Dept Oncol, 401Geniko Stratiotiko Nosokomeio Athenon, Athina 11525, Greece

来源：

GLOBAL MEDICAL GENETICS | 2023年 / 10卷 / 02期

关键词：

genomics; urothelial cancer; liquid biopsy; CIRCULATING TUMOR DNA; BLADDER-CANCER; LIQUID BIOPSIES; LUNG;

D O I：

10.1055/s-0043-1768958

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Early detection of urothelial cancer offers the potential for effective and successful treatment. Despite previous efforts, currently, there is not a well-validated, recommended screening program in any country. This integrative, literature-based review provides details on how recent molecular advances may further advance early tumor detection. The minimally invasive liquid biopsy is capable of identifying tumor material in human fluid samples from asymptomatic individuals. Circulating tumor biomarkers (cfDNA, exosomes, etc.) are very promising and are attracting the interest of numerous studies for the diagnosis of early-stage cancer. However, this approach definitely needs to be refined before clinical implementation. Nevertheless, despite the variety of current obstacles that require further research, the prospect of identifying urothelial carcinoma by a single urine or blood test seems truly intriguing.

引用

页码：101 / 104

页数：4

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