Lecanamab Ushers in a New Era of Anti-Amyloid Therapy for Alzheimer's Disease

被引：5
作者：
Musiek, Erik S. S. [1 ,2 ]
McDade, Eric [1 ,2 ]
Holtzman, David M. M.
机构：
[1] Washington Univ, Hope Ctr Neurol Disorders, Sch Med, Dept Neurol, St. Louis, MO 63130 USA
[2] Washington Univ, Knight Alzheimer Dis Res Ctr, Sch Med, St. Louis, MO 63130 USA
来源：
ANNALS OF NEUROLOGY | 2023年 / 93卷 / 05期
关键词：
PHASE-3; ADUCANUMAB; TRIAL;
D O I：
10.1002/ana.26643
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
[No abstract available]
引用
收藏
页码：877 / 880
页数：4
相关论文
共 19 条
  • [1] Alzheimer's disease drug development pipeline: 2022
    Cummings, Jeffrey
    Lee, Garam
    Nahed, Pouyan
    Kambar, Mina Esmail Zadeh Nojoo
    Zhong, Kate
    Fonseca, Jorge
    Taghva, Kazem
    [J]. ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS, 2022, 8 (01)
  • [2] Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease
    Doody, Rachelle S.
    Thomas, Ronald G.
    Farlow, Martin
    Iwatsubo, Takeshi
    Vellas, Bruno
    Joffe, Steven
    Kieburtz, Karl
    Raman, Rema
    Sun, Xiaoying
    Aisen, Paul S.
    Siemers, Eric
    Liu-Seifert, Hong
    Mohs, Richard
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2014, 370 (04) : 311 - 321
  • [3] A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease
    Doody, Rachelle S.
    Raman, Rema
    Farlow, Martin
    Iwatsubo, Takeshi
    Vellas, Bruno
    Joffe, Steven
    Kieburtz, Karl
    He, Feng
    Sun, Xiaoying
    Thomas, Ronald G.
    Aisen, Paul S.
    Siemers, Eric
    Sethuraman, Gopalan
    Mohs, Richard
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (04) : 341 - 350
  • [4] Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer's Disease
    Egan, Michael F.
    Kost, James
    Tariot, Pierre N.
    Aisen, Paul S.
    Cummings, Jeffrey L.
    Vellas, Bruno
    Sur, Cyrille
    Mukai, Yuki
    Voss, Tiffini
    Furtek, Christine
    Mahoney, Erin
    Mozley, Lyn Harper
    Vandenberghe, Rik
    Mo, Yi
    Michelson, David
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (18) : 1691 - 1703
  • [5] Moving the Needle on Alzheimer's Disease with an Anti-Oligomer Antibody
    Gandy, Sam
    Ehrlich, Michelle E.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2023, 388 (01) : 80 - 81
  • [6] Two Randomized Phase 3 Studies of Aducanumab in Early Alzheimer's Disease
    Haeberlein, S. Budd
    Aisen, P. S.
    Barkhof, F.
    Chalkias, S.
    Chen, T.
    Cohen, S.
    Dent, G.
    Hansson, O.
    Harrison, K.
    von Hehn, C.
    Iwatsubo, T.
    Mallinckrodt, C.
    Mummery, C. J.
    Muralidharan, K. K.
    Nestorov, I.
    Nisenbaum, L.
    Rajagovindan, R.
    Skordos, L.
    Tian, Y.
    van Dyck, C. H.
    Vellas, B.
    Wu, S.
    Zhu, Y.
    Sandrock, A.
    [J]. JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE, 2022, 9 (02): : 197 - 210
  • [7] Donanemab in Early Alzheimer's Disease
    Mintun, Mark A.
    Lo, Albert C.
    Evans, Cynthia Duggan
    Wessels, Alette M.
    Ardayfio, Paul A.
    Andersen, Scott W.
    Shcherbinin, Sergey
    Sparks, JonDavid
    Sims, John R.
    Brys, Miroslaw
    Apostolova, Liana G.
    Salloway, Stephen P.
    Skovronsky, Daniel M.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (18) : 1691 - 1704
  • [8] Evaluating the Safety and Efficacy of Crenezumab vs Placebo in Adults With Early Alzheimer Disease Two Phase 3 Randomized Placebo-Controlled Trials
    Ostrowitzki, Susanne
    Bittner, Tobias
    Sink, Kaycee M.
    Mackey, Howard
    Rabe, Christina
    Honig, Lawrence S.
    Cassetta, Emanuele
    Woodward, Michael
    Boada, Merce
    van Dyck, Christopher H.
    Grimmer, Timo
    Selkoe, Dennis J.
    Schneider, Andres
    Blondeau, Kathleen
    Hu, Nan
    Quartino, Angelica
    Clayton, David
    Dolton, Michael
    Dang, Yifan
    Ostaszewski, Beth
    Sanabria-Bohorquez, Sandra M.
    Rabbia, Michael
    Toth, Balazs
    Eichenlaub, Udo
    Smith, Jillian
    Honigberg, Lee A.
    Doody, Rachelle S.
    [J]. JAMA NEUROLOGY, 2022, 79 (11) : 1113 - 1121
  • [9] Piller C., 2022, SCI TIE 3 CLIN TRIAL
  • [10] The AHEAD 3-45 Study: Design of a prevention trial for Alzheimer's disease
    Rafii, Michael S.
    Sperling, Reisa A.
    Donohue, Michael C.
    Zhou, Jin
    Roberts, Claire
    Irizarry, Michael C.
    Dhadda, Shobha
    Sethuraman, Gopalan
    Kramer, Lynn D.
    Swanson, Chad J.
    Li, David
    Krause, Stephen
    Rissman, Robert A.
    Walter, Sarah
    Raman, Rema
    Johnson, Keith A.
    Aisen, Paul S.
    [J]. ALZHEIMERS & DEMENTIA, 2023, 19 (04) : 1227 - 1233
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