Insight into the role of adult hippocampal neurogenesis in aging and Alzheimer's disease

被引：18

作者：

Chen, Peng ^{[1
,3
]}

Guo, ZhiLei ^{[2
]}

Zhou, Benhong ^{[1
,3
]}

机构：

[1] Wuhan Univ, Dept Pharm, Renmin Hosp, Wuhan, Hubei, Peoples R China

[2] Wuhan Fourth Hosp, Dept Pharm, Wuhan, Hubei, Peoples R China

[3] Wuhan Univ, Dept Pharm, Renmin Hosp, Wuhan 430060, Hubei, Peoples R China

来源：

AGEING RESEARCH REVIEWS | 2023年 / 84卷

基金：

中国国家自然科学基金;

关键词：

Neurogenesis; Adults; Learning and memory; Aging; Alzheimer?s disease; DENTATE GRANULE CELLS; RNA-SEQ; NEUROINFLAMMATION; REVEALS; MEMORY; MODEL; ACTIVATION; MECHANISMS; DEFICITS; BRAIN;

D O I：

10.1016/j.arr.2022.101828

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Alzheimer's disease (AD) is the most common form of dementia and seriously affects the quality of life of the elderly. Neurodegeneration is closely related to hippocampal dysfunction in AD patients. The hippocampus is key to creating new memories and is also one of the first areas of the brain to deteriorate with age. Mammalian neurogenesis occurs mainly in the hippocampus. Recent studies have confirmed that neurogenesis in the hip-pocampus is sustainable but decreases with age, which seriously affects the learning and memory function of AD patients. At present, our understanding of neurogenesis is still relatively shallow, especially pertaining to the influence and role of neurogenesis during aging and cognitive deficits in AD patients. Interestingly, many recent studies have described the characteristics of neurogenesis in animal models. This article reviews the progress of neurogenesis research in the context of aging and AD to provide new insights into neurogenesis.

引用

页数：9

共 92 条

[21] Adult hippocampal neurogenesis reduces memory interference in humans: opposing effects of aerobic exercise and depression [J].

Dery, Nicolas ;

Pilgrim, Malcolm ;

Gibala, Martin ;

Gillen, Jenna ;

Wojtowicz, J. Martin ;

MacQueen, Glenda ;

Becker, Suzanna .

FRONTIERS IN NEUROSCIENCE, 2013, 7

[22] The neuropathological diagnosis of Alzheimer's disease [J].

DeTure, Michael A. ;

Dickson, Dennis W. .

MOLECULAR NEURODEGENERATION, 2019, 14 (01)

[23] Noggin rescues age-related stem cell loss in the brain of senescent mice with neurodegenerative pathology [J].

Diaz-Moreno, Maria ;

Armenteros, Tomas ;

Gradari, Simona ;

Hortiguela, Rafael ;

Garcia-Corzo, Laura ;

Fontan-Lozano, Angela ;

Luis Trejo, Jose ;

Mira, Helena .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (45) :11625-11630

[24] Adult hippocampal neurogenesis in Alzheimer's disease [J].

Disouky, Ahmed ;

Lazarov, Orly .

MOLECULAR BIOLOGY OF NEURODEGENERATIVE DISEASES: VISIONS FOR THE FUTURE, PT B, 2021, 177 :137-156

[25] Molecular Basis of Familial and Sporadic Alzheimer's Disease [J].

Dorszewska, Jolanta ;

Prendecki, Michal ;

Oczkowska, Anna ;

Dezor, Mateusz ;

Kozubski, Wojciech .

CURRENT ALZHEIMER RESEARCH, 2016, 13 (09) :952-963

[26] Single-Cell Metabolomics by Mass Spectrometry Imaging [J].

Duenas, Maria Emilia ;

Lee, Young Jin .

CANCER METABOLOMICS: METHODS AND APPLICATIONS, 2021, 1280 :69-82

[27]

Eiriz MF, 2011, CURR STEM CELL RES T, V6, P288

[28] Aging results in reduced epidermal growth factor receptor signaling, diminished olfactory neurogenesis, and deficits in fine olfactory discrimination [J].

Enwere, E ;

Shingo, T ;

Gregg, C ;

Fujikawa, H ;

Ohta, S ;

Weiss, S .

JOURNAL OF NEUROSCIENCE, 2004, 24 (38) :8354-8365

[29] Mechanisms of Hippocampal Aging and the Potential for Rejuvenation [J].

Fan, Xuelai ;

Wheatley, Elizabeth G. ;

Villeda, Saul A. .

ANNUAL REVIEW OF NEUROSCIENCE, VOL 40, 2017, 40 :251-272

[30] Neurogenesis in the adult hippocampus: history, regulation, and prospective roles [J].

Fares, Jawad ;

Diab, Zeina Bou ;

Nabha, Sanaa ;

Fares, Youssef .

INTERNATIONAL JOURNAL OF NEUROSCIENCE, 2019, 129 (06) :598-611

← 1 2 3 4 5 6 7 8 9 10 →