Insight into the role of adult hippocampal neurogenesis in aging and Alzheimer's disease

被引：18
作者：
Chen, Peng [1 ,3 ]
Guo, ZhiLei [2 ]
Zhou, Benhong [1 ,3 ]
机构：
[1] Wuhan Univ, Dept Pharm, Renmin Hosp, Wuhan, Hubei, Peoples R China
[2] Wuhan Fourth Hosp, Dept Pharm, Wuhan, Hubei, Peoples R China
[3] Wuhan Univ, Dept Pharm, Renmin Hosp, Wuhan 430060, Hubei, Peoples R China
来源：
AGEING RESEARCH REVIEWS | 2023年 / 84卷
基金：
中国国家自然科学基金;
关键词：
Neurogenesis; Adults; Learning and memory; Aging; Alzheimer?s disease; DENTATE GRANULE CELLS; RNA-SEQ; NEUROINFLAMMATION; REVEALS; MEMORY; MODEL; ACTIVATION; MECHANISMS; DEFICITS; BRAIN;
D O I：
10.1016/j.arr.2022.101828
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Alzheimer's disease (AD) is the most common form of dementia and seriously affects the quality of life of the elderly. Neurodegeneration is closely related to hippocampal dysfunction in AD patients. The hippocampus is key to creating new memories and is also one of the first areas of the brain to deteriorate with age. Mammalian neurogenesis occurs mainly in the hippocampus. Recent studies have confirmed that neurogenesis in the hip-pocampus is sustainable but decreases with age, which seriously affects the learning and memory function of AD patients. At present, our understanding of neurogenesis is still relatively shallow, especially pertaining to the influence and role of neurogenesis during aging and cognitive deficits in AD patients. Interestingly, many recent studies have described the characteristics of neurogenesis in animal models. This article reviews the progress of neurogenesis research in the context of aging and AD to provide new insights into neurogenesis.
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页数：9
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