Decreased diffusivity along the perivascular space and cerebral hemodynamic disturbance in adult moyamoya disease

被引：9

作者：

Hara, Shoko ^{[1
,2
,3
,7
]}

Kikuta, Junko ^{[2
]}

Takabayashi, Kaito ^{[2
]}

Kamagata, Koji ^{[2
]}

Hayashi, Shihori ^{[1
,3
]}

Inaji, Motoki ^{[1
,3
]}

Tanaka, Yoji ^{[1
]}

Hori, Masaaki ^{[2
,4
]}

Ishii, Kenji ^{[3
]}

Nariai, Tadashi ^{[1
,3
]}

Taoka, Toshiaki ^{[5
]}

Naganawa, Shinji ^{[6
]}

Aoki, Shigeki ^{[2
]}

Maehara, Taketoshi ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ, Dept Neurosurg, Tokyo, Japan

[2] Juntendo Univ, Dept Radiol, Tokyo, Japan

[3] Tokyo Metropolitan Inst Gerontol, Res Team Neuroimaging, Tokyo, Japan

[4] Toho Univ, Omori Med Ctr, Dept Radiol, Tokyo, Japan

[5] Nagoya Univ, Grad Sch Med, Dept Innovat Biomed Visualizat, Aichi, Japan

[6] Shinshu Univ, Dept Radiol, Aichi, Japan

[7] 1-5-45 Yushima,Bunkyoku, Tokyo 1138510, Japan

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2024年 / 44卷 / 10期

关键词：

Diffusion tensor image analysis along the perivascular space; extracellular fluid; glymphatic system; ischemia; moyamoya disease; GLYMPHATIC SYSTEM; MRI; ISCHEMIA; MOTION;

D O I：

10.1177/0271678X241245492

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Moyamoya disease (MMD) causes cerebral arterial stenosis and hemodynamic disturbance, the latter of which may disrupt glymphatic system activity, the waste clearance system. We evaluated 46 adult patients with MMD and 33 age- and sex-matched controls using diffusivity along the perivascular space (ALPS) measured with diffusion tensor imaging (ALPS index), which may partly reflect glymphatic system activity, and multishell diffusion MRI to generate freewater maps. Twenty-three patients were also evaluated via 15O-gas positron emission tomography (PET), and all patients underwent cognitive tests. Compared to controls, patients (38.4 (13.2) years old, 35 females) had lower ALPS indices in the left and right hemispheres (1.94 (0.27) vs. 1.65 (0.25) and 1.94 (0.22) vs. 1.65 (0.19), P < 0.001). While the right ALPS index showed no correlation, the left ALPS index was correlated with parenchymal freewater (rho = -0.47, P < 0.001); perfusion measured with PET (cerebral blood flow, rho = 0.70, P < 0.001; mean transit time, rho = -0.60, P = 0.003; and oxygen extraction fraction, rho = -0.52, P = 0.003); and cognitive tests (trail making test part B for executive function; rho = -0.37, P = 0.01). Adult patients with MMD may exhibit decreased glymphatic system activity, which is correlated with the degree of hemodynamic disturbance, increased interstitial freewater, and cognitive dysfunction, but further investigation is needed.

引用

页码：1787 / 1800

页数：14

共 54 条

[1]

Agarwal N, 2019, VEINS LYMPH, V8, DOI [10.4081/vl.2019.8470, 10.4081/vl.2019.8470]

[2] Neuroimaging findings related to glymphatic system alterations in older adults with metabolic syndrome [J].