Comparison of Growth Outcomes Between Human Milk-Fed Preterm Infants on Standard Versus Adjustable Fortification Protocols

被引:0
作者
Khorana, Meera [1 ,2 ]
Lamprasertkul, Sareeporn [1 ]
Boonkasidecha, Suppawat [1 ]
机构
[1] Rangsit Univ, Queen Sirikit Natl Inst Child Hlth, Coll Med, Bangkok, Thailand
[2] Queen Sirikit Natl Inst Child Hlth, Neonatal Unit, Pediat, 420-8 Ratchathewi Rd, Bangkok 10400, Thailand
关键词
growth; human milk; human milk fortifier; preterm; PROTEIN FORTIFICATION; BORN;
D O I
10.1089/bfm.2024.0001
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
<bold>Background:</bold> Human milk (HM) is usually fortified using standard fortification (STD) to improve nutrition of preterm infants. However, the protein component may still be insufficient. HM could be further fortified with additional protein to improve STD. <bold>Objective:</bold> The primary objective was to compare changes in body weight (g/day, g/kg/day), length, and head circumference (mm/day) between preterm neonates fed HM with STD and those fed HM with adjustable fortification (ADJ). <bold>Methods:</bold> This study was a prospective, single-blinded, randomized controlled study in preterm infants of gestational age <32 weeks and weighing <= 1,800 g, admitted to the neonatal unit of the Queen Sirikit National Institute of Child Health. Once the infants received full HM feed with STD at 24 kcal/oz, they were randomized to either continue with STD or with ADJ group by adding additional protein to the STD and making further protein adjustments based on the blood urea nitrogen levels. <bold>Results:</bold> Thirty preterm infants completed the study and were randomized into two groups of 15 each. The baseline characteristics, total fluid, and energy intake were similar. Compared with the STD group, infants in the ADJ group exhibited significantly greater weight gain (36.46 +/- 6.09 vs. 25.78 +/- 8.81 g/day; p = 0.001) and greater length gain (1.93 +/- 0.57 vs. 1.12 +/- 0.64 mm/day; p = 0.001). Protein intake significantly correlated with both weight (r = 0.632, p < 0.001) and length gain (r = 0.577, p = 0.001); however, no correlation was found between energy intake, volume intake, and growth outcomes. <bold>Conclusion:</bold> Preterm infants fed with ADJ had significantly higher weight and length gains than those fed with STD, suggesting that additional protein intake may play an important role in growth.
引用
收藏
页码:387 / 393
页数:7
相关论文
共 18 条
  • [1] An intention to achieve better postnatal in-hospital-growth for preterm infants: Adjustable protein fortification of human milk
    Alan, Serdar
    Atasay, Begum
    Cakir, Ufuk
    Yildiz, Duran
    Kilic, Atila
    Kahvecioglu, Dilek
    Erdeve, Omer
    Arsan, Saadet
    [J]. EARLY HUMAN DEVELOPMENT, 2013, 89 (12) : 1017 - 1023
  • [2] Adjustable fortification of human milk fed to preterm infants: does it make a difference?
    Arslanoglu, S.
    Moro, G. E.
    Ziegler, E. E.
    [J]. JOURNAL OF PERINATOLOGY, 2006, 26 (10) : 614 - 621
  • [3] Fortification of Human Milk for Preterm Infants: Update and Recommendations of the European Milk Bank Association (EMBA) Working Group on Human Milk Fortification
    Arslanoglu, Sertac
    Boquien, Clair-Yves
    King, Caroline
    Lamireau, Delphine
    Tonetto, Paola
    Barnett, Debbie
    Bertino, Enrico
    Gaya, Antoni
    Gebauer, Corinna
    Grovslien, Anne
    Moro, Guido E.
    Weaver, Gillian
    Wesolowska, Aleksandra Maria
    Picaud, Jean-Charles
    [J]. FRONTIERS IN PEDIATRICS, 2019, 7
  • [4] Extrauterine growth restriction remains a serious problem in prematurely born neonates
    Clark, RH
    Thomas, P
    Peabody, J
    [J]. PEDIATRICS, 2003, 111 (05) : 986 - 990
  • [5] Protein intakes to optimize outcomes for preterm infants
    Embleton, Nicholas D.
    van den Akker, Chris H. P.
    [J]. SEMINARS IN PERINATOLOGY, 2019, 43 (07)
  • [6] Enteral Nutrition in Preterm Infants (2022): A Position Paper From the ESPGHAN Committee on Nutrition and Invited Experts
    Embleton, Nicholas David
    Jennifer Moltu, Sissel
    Lapillonne, Alexandre
    van den Akker, Chris H. P.
    Carnielli, Virgilio
    Fusch, Christoph
    Gerasimidis, Konstantinos
    van Goudoever, Johannes B.
    Haiden, Nadja
    Iacobelli, Silvia
    Johnson, Mark J.
    Meyer, Sascha
    Mihatsch, Walter
    de Pipaon, Miguel Saenz
    Rigo, Jacques
    Zachariassen, Gitte
    Bronsky, Jiri
    Indrio, Flavia
    Koglmeier, Jutta
    de Koning, Barbara
    Norsa, Lorenzo
    Verduci, Elvira
    Domellof, Magnus
    [J]. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2023, 76 (02) : 248 - 268
  • [7] Gleason C., 2017, Avery's diseases of the newborn, V10th
  • [8] Hair AB., 2019, UPTODATE, V1, P37
  • [9] Kleinman R.E., 2013, Pediatric Nutrition, V7th
  • [10] Human milk fortifier with high versus standard protein content for promoting growth of preterm infants: A meta-analysis
    Liu, Tian-Tian
    Dang, Dan
    Lv, Xiao-Ming
    Wang, Teng-Fei
    Du, Jin-Feng
    Wu, Hui
    [J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2015, 43 (03) : 279 - 289