The neural correlates of topographical disorientation-a lesion analysis study

被引：1

作者：

Blondiaux, Eva ^{[1
,2
]}

Diamantaras, Andreas ^{[3
,4
]}

Schumacher, Rahel ^{[5
]}

Blanke, Olaf ^{[1
,2
,6
]}

Muri, Rene ^{[3
,5
]}

Heydrich, Lukas ^{[3
,4
,7
]}

机构：

[1] Ecole Polytech Fed Lausanne, Lab Cognit Neurosci, Brain Mind Inst, Sch Life Sci, Lausanne, Switzerland

[2] Ecole Polytech Fed Lausanne, Sch Life Sci, Ctr Neuroprosthet, Lausanne, Switzerland

[3] Univ Bern, Bern Univ Hosp, Dept Neurol, Inselspital, Bern, Switzerland

[4] Univ Bern, Bern Univ Hosp, Psychosomat Competence Ctr, Dept Neurol,CORE Lab,Inselspital, Bern, Switzerland

[5] Univ Neurorehabil, Bern Univ Hosp, Univ Bern, Dept Neurol,Inselspital, Bern, Switzerland

[6] Univ Hosp Geneva, Dept Neurol, Geneva, Switzerland

[7] Univ Bern, Bern Univ Hosp, Psychosomat Competence Ctr, Dept Neurol,CORE Lab,Inselspital, CH-3010 Bern, Switzerland

来源：

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY | 2024年 / 11卷 / 02期

基金：

瑞士国家科学基金会;

关键词：

SPATIAL MEMORY; AMNESIA; PATIENT; DAMAGE;

D O I：

10.1002/acn3.51967

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Topographical disorientation refers to the selective inability to orient oneself in familiar surroundings. However, to date its neural correlates remain poorly understood. Here we use quantitative lesion analysis and a lesion network mapping approach in order to investigate seven patients with topographical disorientation. Our findings link not only the posterior parahippocampal gyrus (PHG) and retrosplenial cortex but also the lingual gyrus, the precuneus and the fusiform gyrus to topographical disorientation. We propose that topographical disorientation is due to the inability to integrate familiar landmarks within a framework of allocentric and egocentric orientation, supported by a neural network including the posterior PHG, the retrosplenial and the lingual cortex.

引用

页码：520 / 524

页数：5

共 19 条

[1] Topographical disorientation: a synthesis and taxonomy [J].