Molecular Mechanisms of Ferroptosis and Their Involvement in Acute Kidney Injury

被引：8

作者：

Liu, Jie ^{[1
]}

Han, Xiaoxia ^{[1
]}

Zhou, Jia ^{[1
]}

Leng, Yufang ^{[1
,2
]}

机构：

[1] Lanzhou Univ, Sch Clin Med 1, Lanzhou, Peoples R China

[2] Lanzhou Univ, Hosp 1, Dept Anesthesiol, Lanzhou, Peoples R China

来源：

JOURNAL OF INFLAMMATION RESEARCH | 2023年 / 16卷

关键词：

ferroptosis; iron; lipid peroxidation; molecular mechanism; acute kidney injury; CELL-DEATH; DEGRADATION; PATHOPHYSIOLOGY; PEROXIDATION; EXPRESSION; AUTOPHAGY; DISEASE; SYSTEM; NCOA4;

D O I：

10.2147/JIR.S427505

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ferroptosis is a novel way of regulating cell death, which occurs in a process that is closely linked to intracellular iron metabolism, lipid metabolism, amino acid metabolism, and multiple signaling pathways. The latest research shows that ferroptosis plays a key role in the pathogenesis of acute kidney injury (AKI). Ferroptosis may be an important target for treating AKI caused by various reasons, such as ischemia-reperfusion injury, rhabdomyolysis syndrome, sepsis, and nephrotoxic drugs. This paper provides a review on the regulatory mechanisms of ferroptosis and its role in AKI, which may help to provide new research ideas for the treatment of AKI and future research.

引用

页码：4941 / 4951

页数：11

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