Gallium(III)- and Thallium(III)-Encapsulated Polyoxopalladates: Synthesis, Structure, Multinuclear NMR, and Biological Activity Studies

被引：5

作者：

Ma, Tian ^{[1
]}

Ma, Xiang ^{[1
]}

Lin, Zhengguo ^{[1
,7
]}

Zhang, Jiayao ^{[1
]}

Yang, Peng ^{[1
,2
]}

Csupasz, Tibor ^{[3
]}

Toth, Imre ^{[3
]}

Misirlic-Dencic, Sonja ^{[4
,5
]}

Isakovic, Andjelka M. ^{[4
,5
]}

Lembo, David ^{[6
]}

Donalisio, Manuela ^{[6
]}

Kortz, Ulrich ^{[1
]}

机构：

[1] Constructor Univ, Sch Sci, D-28759 Bremen, Germany

[2] Hunan Univ, Coll Chem & Chem Engn, Adv Catalyt Engn Res Ctr, Minist Educ, Changsha 410082, Peoples R China

[3] Univ Debrecen, Dept Phys Chem, H-4032 Debrecen, Hungary

[4] Univ Belgrade, Inst Med & Clin Biochem, Fac Med, Belgrade 11000, Serbia

[5] Ctr Excellence Redox Med, Belgrade 11000, Serbia

[6] Univ Turin, Dept Clin & Biol Sci, Lab Mol Virol & Antiviral Res, I-10043 Orbassano, Italy

[7] Hebei Normal Univ, Coll Chem & Mat Sci, Shijiazhuang 050024, Peoples R China

来源：

INORGANIC CHEMISTRY | 2023年 / 62卷 / 33期

基金：

中国国家自然科学基金;

关键词：

ANTIBACTERIAL ACTIVITY; MECHANISM; CHEMISTRY;

D O I：

10.1021/acs.inorgchem.3c01530

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The phosphate-capped 12-palladate nanocubes[XPd12O8(PO4)(8)](13-) (X= Ga-III, GaPd ( 12 ) P ( 8 ); X = Tl-III, TlPd ( 12 ) P ( 8 )) and the 23-palladate double-cube [Tl-2 (Pd23P14O70)-Pd-III(OH)(2)](20-) (Tl ( 2 ) Pd ( 23 ) P ( 14 )) have beenprepared and characterized in the solid state and in solution by P-31, Ga-71, and Tl-205 NMR. Biologicalstudies demonstrated the antitumor and antiviral activities of GaPd ( 12 ) P ( 8 ) and TlPd ( 12 ) P ( 8 ) being as efficient as cis-platinum against human melanoma and acute promyelocytic leukemiacells, exerting inhibitory activity against two herpetic viruses,HSV-2 and HCMV, in a dose-response manner. Three gallium(III)- and thallium(III)-containing polyoxopalladates(POPs) have been synthesized and structurally characterized in thesolid state and in solution, namely, the phosphate-capped 12-palladatenanocubes [XPd12O8(PO4)(8)](13-) (X = Ga-III, GaPd ( 12 ) P ( 8 ); X =Tl-III, TlPd ( 12 ) P ( 8 )) and the 23-palladate double-cube[Tl-2 (Pd23P14O70)-Pd-III(OH)(2)](20-) (Tl ( 2 ) Pd ( 23 ) P ( 14 )). The cuboid POPs, GaPd ( 12 ) P ( 8 ) and TlPd ( 12 ) P ( 8 ), are solution stable as verified by the respective P-31, Ga-71, and Tl-205 nuclear magnetic resonance(NMR) spectra. Of prime interest, the spin-spin coupling schemesallowed for an intimate study of the solution behavior of the Tl-III-containing POPs via a combination of P-31 and Tl-205 NMR, including the stoichiometry of the major fragmentsof Tl ( 2 ) Pd ( 23 ) P ( 14 ). Moreover,biological studies demonstrated the antitumor and antiviral activityof GaPd ( 12 ) P ( 8 ) and TlPd ( 12 ) P ( 8 ), which were validated to be asefficient as cis-platinum against human melanomaand acute promyelocytic leukemia cells. Furthermore, GaPd ( 12 ) P ( 8 ) and TlPd ( 12 ) P ( 8 ) exerted inhibitory activity against two herpeticviruses, HSV-2 and HCMV, in a dose-response manner.

引用

页码：13195 / 13204

页数：10

共 41 条

[21] Selected polyoxopalladates as promising and selective antitumor drug candidates [J].