Intraosseous hibernoma: clinicopathologic and imaging analysis of 18 cases

被引:3
作者
Gangahar, Chiraag N. [1 ]
Dehner, Carina A. [1 ]
Wang, David P. [2 ]
Amini, Behrang [3 ]
Hillen, Travis [4 ]
O'Conor, Christopher [5 ]
Jennings, Sydney N. [6 ]
Byrnes, Kathleen
Montgomery, Elizabeth A. [7 ]
Czerniak, Bogdan A. [2 ]
Bridge, Julia A. [8 ,9 ]
Schroeder, Molly C.
Jennings, Jack W. [4 ]
Wang, Wei-Lien [2 ]
Chrisinger, John S. A. [1 ,10 ]
机构
[1] Washington Univ, Dept Pathol & Immunol, Sch Med, St Louis, MO USA
[2] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX USA
[3] Univ Texas MD Anderson Canc Ctr, Dept Diagnost Imaging, Houston, TX USA
[4] Washington Univ, Mallinckrodt Inst Radiol, Dept Radiol, Musculoskeletal Sect,Sch Med, St Louis, MO USA
[5] Vanderbilt Univ, Dept Pathol Microbiol & Immunol, Med Ctr, Nashville, TN USA
[6] Washington Univ, St Louis, MO USA
[7] Univ Miami, Dept Pathol & Lab Med, Miami, FL USA
[8] Propath, Dallas, TX USA
[9] Univ Nebraska Med Ctr, Dept Pathol & Microbiol, Omaha, NE USA
[10] Washington Univ, Sch Med, Dept Pathol & Immunol, 660 South Euclid Ave,Campus Box 8118, St Louis, MO 63110 USA
关键词
benign adipocytic; bone; brown fat; intraosseous hibernoma; BROWN FAT; BONE-MARROW; RARE; DELETIONS; AIP;
D O I
10.1111/his.14928
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
AimsIntraosseous hibernomas are rarely reported tumours with brown adipocytic differentiation of unknown aetiology, with only 38 cases documented in the literature. We sought to further characterise the clinicopathologic, imaging and molecular features of these tumours. Methods and resultEighteen cases were identified occurring in eight females and 10 males (median age = 65 years, range = 7-75). Imaging indication was cancer surveillance/staging in 11 patients and clinical concern for a metastasis was raised in 13 patients. The innominate bone (7), sacrum (5), mobile spine (4), humerus (1) and femur (1) were involved. Median tumour size was 1.5 cm (range = 0.8-3.8). Tumours were sclerotic (11), mixed sclerotic and lytic (4) or occult (1). Microscopically, tumours were composed of large polygonal cells with distinct cell membranes, finely vacuolated cytoplasm, central or paracentral small bland nuclei with prominent scalloping. Growth around trabecular bone was observed. Tumour cells were immunoreactive for S100 protein (15/15) and adipophilin (5/5), while negative for keratin AE1/AE3(/PCK26) (0/14) and brachyury (0/2). Chromosomal microarray analysis, performed on four cases, did not show clinically significant copy number variation across the genome or on 11q, the site of AIP and MEN1. ConclusionAnalysis of 18 cases of intraosseous hibernoma, to our knowledge, the largest series to date, revealed that these tumours are most often detected in the spine and pelvis of older adults. Tumours were generally small, sclerotic and frequently found incidentally and can raise concern for metastasis. Whether or not these tumours are related to soft tissue hibernomas is uncertain.
引用
收藏
页码:40 / 48
页数:9
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