Palladium-Catalyzed Regioselective Carbonylation of 2-Trifluoromethyl-1,3-enynes to Multisubstituted Conjugated Dienes

被引：7
|
作者：
Kuai, Chang-Sheng [1 ,2 ]
Teng, Bing-Hong [1 ,3 ]
An, Da-Lie [1 ,2 ]
Zhao, Yingying [3 ]
Wu, Xiao-Feng [1 ,2 ,4 ]
机构：
[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian Natl Lab Clean Energy, Dalian 116023, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Liaoning Normal Univ, Sch Chem & Chem Engn, Dalian 116029, Peoples R China
[4] Leibniz Inst Katalyse eV, D-18059 Rostock, Germany
来源：
ORGANIC LETTERS | 2023年
关键词：
ALKENES; ALKYNES; OLEFINATION; EFFICIENT; ENYNES; HYDROESTERIFICATION; PHOSPHATES; COMPLEX;
D O I：
10.1021/acs.orglett.2c04331
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In this communication, a palladium-catalyzed regio-and stereoselective carbonylation of 2-trifluoromethyl-1,3-enynes to afford multisubstituted conjugated dienes has been realized. This protocol features excellent regio-and exclusive (E)-stereoselectivity and a broad substrate scope with both amines and alcohols as the suitable reaction partners and has shown promising functional group tolerance.
引用
收藏
页码：682 / 687
页数：6
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