Novel BRD2::NUTM1 Fusion in NUT Carcinoma With Exceptional Response to Chemotherapy: A Case Report

被引：1

作者：

Wu, Sarah J. ^{[1
]}

Kim, Justin J. ^{[2
,3
]}

Huang, Yeying ^{[1
]}

Durall, R. Taylor ^{[1
]}

Becker, Simone ^{[2
]}

Canty, Stephanie ^{[2
]}

Molinaro, Stefania ^{[2
]}

Pisick, Evan ^{[4
]}

Shapiro, Geoffrey I. ^{[5
,6
]}

French, Christopher A. ^{[1
]}

Luo, Jia ^{[2
,5
,7
]}

机构：

[1] Brigham & Womens Hosp, Dept Pathol, Boston, MA USA

[2] Dana Farber Canc Inst, Lowe Ctr Thorac Oncol, Dept Med Oncol, Boston, MA 02215 USA

[3] Colby Coll, Dept Biol, Waterville, ME USA

[4] City Hope Chicago, Zion, IL USA

[5] Brigham & Womens Hosp, Dept Med, Boston, MA USA

[6] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA USA

[7] Dana Farber Canc Inst, Lowe Ctr Thorac Oncol, Dept Med Oncol, 450 Brookline Ave LC4116, Boston, MA 02215 USA

来源：

JTO CLINICAL AND RESEARCH REPORTS | 2024年 / 5卷 / 01期

关键词：

Case report; NUT carcinoma; BRD2; NUTM1 gene fusion; Non-small cell lung cancer;

D O I：

10.1016/j.jtocrr.2023.100625

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We present the first known case of a patient with BRD2::NUTM1-driven NUT carcinoma. A 59 -year -old woman presented with poorly differentiated squamous cell lung cancer metastatic to the pleura. Eventually, a positive NUT immunohistochemistry, NUT fluorescence in situ hybridization, and RNA next -generation sequencing with a BRD2::NUTM1 fusion led to the diagnosis of NUT carcinoma. She received multiple lines of chemotherapy with response and is still alive at 2 years postdiagnosis. This report expands on the known fusions in NUT carcinoma and highlights potential differences in patient prognosis on the basis of gene fusion partners. (c) 2023 The Authors. Published by Elsevier Inc. on behalf of the International Association for the Study of Lung Cancer. This is an open access article under the CC BY -NC -ND license (http://creativecommons.org/licenses/by-nc-nd/ 4.0/).

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