Therapeutic strategies targeting cellular senescence for cancer and other diseases

被引：5
作者：
Wang, Xuebing [1 ]
Fukumoto, Takeshi [2 ]
Noma, Ken-ichi [1 ,3 ]
机构：
[1] Hokkaido Univ, Inst Genet Med, Kita 15,Nishi 7,Kita Ku, Sapporo 0600815, Japan
[2] Kobe Univ, Grad Sch Med, Dept Internal Related, Div Dermatol, 7-5-1 Kusunoki Cho,Chuo Ku, Kobe 6500017, Japan
[3] Univ Oregon, Inst Mol Biol, 1370 Franklin Blvd, Eugene, OR 97403 USA
来源：
JOURNAL OF BIOCHEMISTRY | 2024年 / 175卷 / 05期
关键词：
aging; cancer; cellular senescence; premature aging (progeria) syndromes; senescence- and aging-related diseases; senolytic agents; ONCOGENE-INDUCED SENESCENCE; SECRETORY PHENOTYPE; HUMAN FIBROBLASTS; GROWTH-FACTOR; CYCLE ARREST; STEM-CELLS; DARK SIDE; P53; BCL-2; HETEROCHROMATIN;
D O I：
10.1093/jb/mvae015
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cellular senescence occurs in response to endogenous or exogenous stresses and is characterized by stable cell cycle arrest, alterations in nuclear morphology and secretion of proinflammatory factors, referred to as the senescence-associated secretory phenotype (SASP). An increase of senescent cells is associated with the development of several types of cancer and aging-related diseases. Therefore, senolytic agents that selectively remove senescent cells may offer opportunities for developing new therapeutic strategies against such cancers and aging-related diseases. This review outlines senescence inducers and the general characteristics of senescent cells. We also discuss the involvement of senescent cells in certain cancers and diseases. Finally, we describe a series of senolytic agents and their utilization in therapeutic strategies. Graphical Abstract
引用
收藏
页码：525 / 537
页数：13
相关论文
共 131 条
  • [41] TELOMERES SHORTEN DURING AGING OF HUMAN FIBROBLASTS
    HARLEY, CB
    FUTCHER, AB
    GREIDER, CW
    [J]. NATURE, 1990, 345 (6274) : 458 - 460
  • [42] SERIAL CULTIVATION OF HUMAN DIPLOID CELL STRAINS
    HAYFLICK, L
    MOORHEAD, PS
    [J]. EXPERIMENTAL CELL RESEARCH, 1961, 25 (03) : 585 - +
  • [43] Hutchinson-Gifford Progeria syndrome: Review of the phenotype
    Hennekam, Raoul C. M.
    [J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2006, 140A (23) : 2603 - 2624
  • [44] Hallmarks of Cellular Senescence
    Hernandez-Segura, Alejandra
    Nehme, Jamil
    Demaria, Marco
    [J]. TRENDS IN CELL BIOLOGY, 2018, 28 (06) : 436 - 453
  • [45] Unmasking Transcriptional Heterogeneity in Senescent Cells
    Hernandez-Segura, Alejandra
    de Jong, Tristan V.
    Melov, Simon
    Guryev, Victor
    Campisi, Judith
    Demaria, Marco
    [J]. CURRENT BIOLOGY, 2017, 27 (17) : 2652 - +
  • [46] mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype (vol 17, 1205, 2015)
    Herranz, Nicolas
    Gallage, Suchira
    Mellone, Massimiliano
    Wuestefeld, Torsten
    Klotz, Sabrina
    Hanley, Christopher J.
    Raguz, Selina
    Acosta, Juan Carlos
    Innes, Andrew J.
    Banito, Ana
    Georgilis, Athena
    Montoya, Alex
    Wolter, Katharina
    Dharmalingam, Gopuraja
    Faull, Peter
    Carroll, Thomas
    Martinez-Barbera, Juan Pedro
    Cutillas, Pedro
    Reisinger, Florian
    Heikenwalder, Mathias
    Miller, Richard A.
    Withers, Dominic
    Zender, Lars
    Thomas, Gareth J.
    Gil, Jesus
    [J]. NATURE CELL BIOLOGY, 2015, 17 (09) : 1205 - +
  • [47] Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
    Hickson, LaTonya J.
    Prata, Larissa G. P. Langhi
    Bobart, Shane A.
    Evans, Tamara K.
    Giorgadze, Nino
    Hashmi, Shahrukh K.
    Herrmann, Sandra M.
    Jensen, Michael D.
    Jia, Qingyi
    Jordan, Kyra L.
    Kellogg, Todda.
    Khosla, Sundeep
    Koerber, Daniel M.
    Lagnado, Anthony B.
    Lawson, Donna K.
    LeBrasseur, Nathan K.
    Lerman, Lilach O.
    McDonald, Kathleen M.
    McKenzie, Travis J.
    Passos, Joao F.
    Pignolo, Robert J.
    Pirtskhalava, Tamar
    Saadiq, Ishran M.
    Schaefer, Kalli K.
    Textor, Stephen C.
    Victorelli, Stella G.
    Volkman, Tammie L.
    Xue, Ailing
    Wentworth, Mark A.
    Gerdes, Erin O. Wissler
    Zhu, Yi
    Tchkonia, Tamara
    Kirkland, James L.
    [J]. EBIOMEDICINE, 2019, 47 : 446 - 456
  • [48] NOTCH1 mediates a switch between two distinct secretomes during senescence
    Hoare, Matthew
    Ito, Yoko
    Kang, Tae-Won
    Weekes, Michael P.
    Matheson, Nicholas J.
    Patten, Daniel A.
    Shetty, Shishir
    Parry, Aled J.
    Menon, Suraj
    Salama, Rafik
    Antrobus, Robin
    Tomimatsu, Kosuke
    Howat, William
    Lehner, Paul J.
    Zender, Lars
    Narita, Masashi
    [J]. NATURE CELL BIOLOGY, 2016, 18 (09) : 979 - 992
  • [49] Lysosome-mediated processing of chromatin in senescence
    Ivanov, Andre
    Pawlikowski, Jeff
    Manoharan, Indrani
    van Tuyn, John
    Nelson, David M.
    Rai, Taranjit Singh
    Shah, Parisha P.
    Hewitt, Graeme
    Korolchuk, Viktor I.
    Passos, Joao F.
    Wu, Hong
    Berger, Shelley L.
    Adams, Peter D.
    [J]. JOURNAL OF CELL BIOLOGY, 2013, 202 (01) : 129 - 143
  • [50] Co-targeting BCL-XL and BCL-2 by PROTAC 753B eliminates leukemia cells and enhances efficacy of chemotherapy by targeting senescent cells
    Jia, Yannan
    Han, Lina
    Ramage, Cassandra L.
    Wang, Zhe
    Weng, Connie C.
    Yang, Lei
    Colla, Simona
    Ma, Helen
    Zhang, Weiguo
    Andreeff, Michael
    Daver, Naval
    Jain, Nitin
    Pemmaraju, Naveen
    Bhalla, Kapil
    Mustjoki, Satu
    Zhang, Peiyi
    Zheng, Guangrong
    Zhou, Daohong
    Zhang, Qi
    Konopleva, Marina
    [J]. HAEMATOLOGICA, 2023, 108 (10) : 2626 - 2638
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