Therapeutic strategies targeting cellular senescence for cancer and other diseases

被引：5
作者：
Wang, Xuebing [1 ]
Fukumoto, Takeshi [2 ]
Noma, Ken-ichi [1 ,3 ]
机构：
[1] Hokkaido Univ, Inst Genet Med, Kita 15,Nishi 7,Kita Ku, Sapporo 0600815, Japan
[2] Kobe Univ, Grad Sch Med, Dept Internal Related, Div Dermatol, 7-5-1 Kusunoki Cho,Chuo Ku, Kobe 6500017, Japan
[3] Univ Oregon, Inst Mol Biol, 1370 Franklin Blvd, Eugene, OR 97403 USA
来源：
JOURNAL OF BIOCHEMISTRY | 2024年 / 175卷 / 05期
关键词：
aging; cancer; cellular senescence; premature aging (progeria) syndromes; senescence- and aging-related diseases; senolytic agents; ONCOGENE-INDUCED SENESCENCE; SECRETORY PHENOTYPE; HUMAN FIBROBLASTS; GROWTH-FACTOR; CYCLE ARREST; STEM-CELLS; DARK SIDE; P53; BCL-2; HETEROCHROMATIN;
D O I：
10.1093/jb/mvae015
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cellular senescence occurs in response to endogenous or exogenous stresses and is characterized by stable cell cycle arrest, alterations in nuclear morphology and secretion of proinflammatory factors, referred to as the senescence-associated secretory phenotype (SASP). An increase of senescent cells is associated with the development of several types of cancer and aging-related diseases. Therefore, senolytic agents that selectively remove senescent cells may offer opportunities for developing new therapeutic strategies against such cancers and aging-related diseases. This review outlines senescence inducers and the general characteristics of senescent cells. We also discuss the involvement of senescent cells in certain cancers and diseases. Finally, we describe a series of senolytic agents and their utilization in therapeutic strategies. Graphical Abstract
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收藏
页码：525 / 537
页数：13
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